Adult Cognitive DiseaseThe research corpus Monographs

Oskar Fischer Prize — Knowledge Base

A structured knowledge base covering 151 Alzheimer's disease hypotheses submitted to the 2022 Oskar Fischer Prize ($4M, 10 winners).

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Prize Winners

Gold ($500K): Estela Area-Gomez · Bess Frost · Ralph Nixon · Carlo Abbate

Silver ($400K): Bernd Moosmann · Donald Weaver

Bronze ($300K): Annelise Barron · Gunnar Gouras · Varghese John · Russell Swerdlow

Convergence Nodes (CSC Framework)

  1. Endosomal Nexus — Receptor trafficking & endosomal convergence
  2. Cytoskeletal Collapse — Dendritic spine & cytoskeleton failure
  3. Compensatory Paradigm — Protective responses turned pathological
  4. Neuroimmune Interface — Complement-microglial pruning cascade
  5. APOE4 Hub — Multi-mechanism genetic risk factor
  6. Transcriptional-Epigenetic Dysregulation — Gene expression lock-in

Temporal Stages

  1. Molecular Initiation (Years -30 to -15)
  2. Endosomal Dysregulation (Years -15 to -5)
  3. Cytoskeletal Perturbation (Years -5 to 0)
  4. Neuroimmune Activation (Years 0 to 5)
  5. Network Disintegration (Years 5 to 15)

External Scientists

Key AD researchers whose work supports, extends, or contradicts the prize entrant theories. 81 scientists across all major AD domains.

By domain: Amyloid immunotherapy · Tau biology · Neuroinflammation/microglia · Endolysosomal/autophagy · Lipid/ApoE · Ferroptosis · Infectious hypothesis · Genetics/GWAS · Biomarkers · Synaptic biology · Vascular/BBB · Clinical trials

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Note: wiki/pathways/ is reserved but not yet populated — molecular pathways currently live inline in concept pages. See ../AGENTS.md for vault schema and conventions.

Tools

Tool Command
Generate researcher stubs python kb/tools/ingest.py scaffold
Enrich from PubMed data python kb/tools/enrich.py <data.json>
Rebuild catalog + index python kb/tools/build_catalog.py
Health check python kb/tools/lint.py

Status

Karpathy-pattern alignment complete (2026-06-10). Vault now has AGENTS.md (schema), log.md (append-only history), and index.md (complete catalog). Lint is clean: 0 errors, 0 broken wikilinks, 0 orphans. The vault held, at that date, 151 entrants, 96 external scientists, 626 concepts and 7 convergence nodes; the corpus has moved since, and the live counts are the ones in the footer of every page. 36 entrants reviewed (DeepResearch). CSC grading (Phase 3) and raw paper extraction (Phase 4) remain. ~117 newly-created concept pages are stubs (status: stub) awaiting enrichment.

Important noticeThis is a research platform, not a medical site. Nothing here is medical advice, a diagnosis, or a treatment recommendation, and none of it has been reviewed by a regulator. The drugs, doses and trials discussed are research literature, not prescriptions. If dementia affects you or someone you care about, speak to a doctor.

Compiled from the knowledge base and the research corpus under the Organic Network Synthesis methodology · the research corpus of Adult Cognitive Disease · the seven monographs are here. 2026.

827 interlinked articles · 120 papers in full · 53 as typeset PDFs · 635 concepts · 7 convergence nodes · 5 temporal stages.

Discussion

Corrections and disagreements are welcome here, and citation corrections most of all. Posting needs a GitHub account. Please read Taking Part first — in particular, nothing here is medical advice.