Adult Cognitive DiseaseThe research corpus Monographs

Stage 5: Network Disintegration

Years 5 to 15

Timeframe: Years 5 to 15 after clinical onset

Widespread neuronal death, tau tangles, plaques. Severe dementia. All convergence nodes are now maximally active and synergistically destructive.

Key Events

  • Widespread neuronal death
  • Tau tangles and amyloid plaques fully established
  • Severe dementia
  • All convergence nodes maximally active

Previous Stage

Neuroimmune Activation

Last reviewed 5 April 2026.

Important noticeThis is a research platform, not a medical site. Nothing here is medical advice, a diagnosis, or a treatment recommendation, and none of it has been reviewed by a regulator. The drugs, doses and trials discussed are research literature, not prescriptions. If dementia affects you or someone you care about, speak to a doctor.

Compiled from the knowledge base and the research corpus under the Organic Network Synthesis methodology · the research corpus of Adult Cognitive Disease · the seven monographs are here. 2026.

827 interlinked articles · 120 papers in full · 53 as typeset PDFs · 635 concepts · 7 convergence nodes · 5 temporal stages.

Discussion

Corrections and disagreements are welcome here, and citation corrections most of all. Posting needs a GitHub account. Please read Taking Part first — in particular, nothing here is medical advice.