Adult Cognitive DiseaseThe research corpus Monographs

Stage 4: Neuroimmune Activation

Years 0 to 5

Timeframe: Years 0 to 5 after clinical onset

Complement cascade activated, microglial pruning accelerates. Progressive synaptic loss. Mild-to-moderate cognitive impairment.

Key Events

  • Complement cascade activation
  • Microglial pruning accelerates
  • Progressive synaptic loss
  • Mild-to-moderate impairment

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Cytoskeletal Perturbation | Network Disintegration

Last reviewed 5 April 2026.

Important noticeThis is a research platform, not a medical site. Nothing here is medical advice, a diagnosis, or a treatment recommendation, and none of it has been reviewed by a regulator. The drugs, doses and trials discussed are research literature, not prescriptions. If dementia affects you or someone you care about, speak to a doctor.

Compiled from the knowledge base and the research corpus under the Organic Network Synthesis methodology · the research corpus of Adult Cognitive Disease · the seven monographs are here. 2026.

827 interlinked articles · 120 papers in full · 53 as typeset PDFs · 635 concepts · 7 convergence nodes · 5 temporal stages.

Discussion

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