Adult Cognitive Disease

APOE Amyloid & Tau core 2,803 442 docs

Matched on apoe[234]? apo[- ]?E[234]? apolipoprotein E

Often named withAPP PSEN1 TREM2 V-ATPase (ATP6V)LRP8 (ApoER2)BACE1

RELN Reelin, synapse & ECM–PNN 1,916 41 docs

Matched on RELN reelin

Often named withAPOE LRP8 (ApoER2)PSEN1 APP DAB1 VLDLR

APP Amyloid & Tau core 778 144 docs

Matched on amyloid precursor protein APP

Often named withAPOE PSEN1 BACE1 LRP8 (ApoER2)ACAN (aggrecan)NLRP3

TREM2 GWAS / LOAD risk 514 64 docs

Matched on s?TREM2

Often named withAPOE NLRP3 APP PSEN1 C1QA C3

NLRP3 Microglia & innate immunity 467 49 docs

Matched on NLRP3

Often named withAPOE TREM2 APP PSEN1 ACAN (aggrecan)C1QA

LRP8 (ApoER2) Reelin, synapse & ECM–PNN 413 46 docs

Matched on LRP8 ApoER2 APOER2

Often named withAPOE RELN APP DAB1 PSEN1 VLDLR

MMP9 Reelin, synapse & ECM–PNN 391 44 docs

Matched on MMP-?9

Often named withAPOE ACAN (aggrecan)APP MMP2 BCAN (brevican)PSEN1

LILRB2 GWAS / LOAD risk 371 20 docs

Matched on LILRB2 PirB

Often named withAPOE C4 (complement)C1QA APP TREM2 C3

CD38 Bioenergetic / mito / NAD 356 27 docs

Matched on CD38

Often named withAPOE PARP1 TREM2 APP MTOR MMP2

DAB1 Reelin, synapse & ECM–PNN 326 29 docs

Matched on DAB1 Disabled-1

Often named withLRP8 (ApoER2)APOE PSEN1 RELN APP VLDLR

BDNF Trophic / exercise / resilience 297 21 docs

Matched on BDNF

Often named withAPOE APP PSEN1 GRIN2B MTOR TARDBP (TDP-43)

PSEN1 Amyloid & Tau core 257 98 docs

Matched on PSEN1 PS1 presenilin[- ]?1

Often named withAPP APOE LRP8 (ApoER2)RELN ACAN (aggrecan)DAB1

ACAN (aggrecan) Reelin, synapse & ECM–PNN 256 45 docs

Matched on ACAN aggrecan

Often named withAPOE APP MMP9 PSEN1 BCAN (brevican)TNR (tenascin-R)

HSD17B10 Bioenergetic / mito / NAD 241 4 docs

Matched on HSD17B10 HSD10 ABAD 17β-HSD10 17beta-HSD10

Often named withAPP APOE PINK1 TIMM23 TOM40 TOMM20

SORL1 GWAS / LOAD risk 232 31 docs

Matched on SORL1 SORLA

Often named withAPOE C1QA APP C3 CR3 PSEN1

V-ATPase (ATP6V) Autophagy / lysosome / clearance 220 59 docs

Matched on V-ATPase ATP6V vacuolar[- ]?(?:type )?ATPase

Often named withAPOE APP PSEN1 TREM2 TFEB BACE1

VCAM1 Vascular / BBB 195 6 docs

Matched on VCAM-?1

Often named withPARP1 APOE LRP1 MMP9 APP CX3CR1

ARHGEF15 (Ephexin5) Reelin, synapse & ECM–PNN 189 9 docs

Matched on Ephexin-?5 ARHGEF15

Often named withAPOE C4 (complement)LILRB2 APP C1QA DAB1

GPX4 Oxidative stress & ferroptosis 189 17 docs

Matched on GPX4

Often named withAPOE APP PSEN1 LRP8 (ApoER2)PARP1 MTOR

PARP1 Bioenergetic / mito / NAD 182 26 docs

Matched on PARP-?1 PARP1

Often named withAPOE APP MMP9 ACAN (aggrecan)P2RY12 C1QA

IDO1 Neuromodulator / circadian / kynurenine 175 10 docs

Matched on IDO1 IDO

Often named withAPOE APP IL6 KMO PSEN1 TNF

C4 (complement) Microglia & innate immunity 171 23 docs

Matched on C4d C4b

Often named withAPOE C1QA C3 LILRB2 TREM2 MMP9

TOMM40 Bioenergetic / mito / NAD 140 18 docs

Matched on TOMM40

Often named withAPOE APP TOM40 V-ATPase (ATP6V)PINK1 TARDBP (TDP-43)

C1QA Microglia & innate immunity 137 40 docs

Matched on C1q C1QA C1QB

Often named withAPOE C3 CR3 APP TREM2 C4 (complement)

TARDBP (TDP-43) Neurodegeneration overlap 134 27 docs

Matched on TARDBP TDP-?43

Often named withAPP APOE PSEN1 TREM2 RELN BACE1

BACE1 Amyloid & Tau core 133 46 docs

Matched on BACE1

Often named withAPOE APP PSEN1 TREM2 V-ATPase (ATP6V)ADAM10

PYCARD Microglia & innate immunity 112 12 docs

Matched on PYCARD ASC

Often named withNLRP3 APP CASP1 PSEN1 TREM2 ACAN (aggrecan)

MTOR Autophagy / lysosome / clearance 110 24 docs

Matched on mTOR MTOR mTORC1 mTORC2

Often named withPSEN1 APP TREM2 APOE NLRP3 P2RY12

TNF Microglia & innate immunity 105 32 docs

Matched on TNF

Often named withAPOE TREM2 APP IL6 MMP9 NLRP3

VLDLR Reelin, synapse & ECM–PNN 96 22 docs

Matched on VLDLR

Often named withDAB1 LRP8 (ApoER2)RELN APOE PSEN1 APP

GSK3B Amyloid & Tau core 93 38 docs

Matched on GSK3B GSK-?3β GSK-?3beta GSK-?3

Often named withAPOE APP PSEN1 LRP8 (ApoER2)DAB1 RELN

TOM40 Bioenergetic / mito / NAD 88 9 docs

Matched on TOM40

Often named withAPOE APP PINK1 PRKN TOMM20 NLRP3

C3 Microglia & innate immunity 86 37 docs

Matched on C3

Often named withC1QA APOE CR3 APP TREM2 C4 (complement)

CASP1 Microglia & innate immunity 81 13 docs

Matched on CASP1 caspase[- ]?1

Often named withNLRP3 APP PSEN1 ACAN (aggrecan)APOE PYCARD

MAOA/MAOB Neuromodulator / circadian / kynurenine 80 8 docs

Matched on MAO-A MAO-B MAOA MAOB monoamine oxidase

Often named withAPOE APP IDO1 ACAN (aggrecan)BDNF KMO

PINK1 Bioenergetic / mito / NAD 78 13 docs

Matched on PINK1

Often named withAPOE PRKN APP TREM2 ACAN (aggrecan)C1QA

BCAN (brevican) Reelin, synapse & ECM–PNN 74 23 docs

Matched on BCAN brevican

Often named withACAN (aggrecan)MMP9 APOE NCAN (neurocan)APP VCAN (versican)

LRP1 Reelin, synapse & ECM–PNN 74 20 docs

Matched on LRP1

Often named withAPOE APP MMP9 PSEN1 ACAN (aggrecan)LRP8 (ApoER2)

BIN1 GWAS / LOAD risk 68 18 docs

Matched on BIN1

Often named withAPOE APP DNM2 SORL1 TREM2 PARP1

CR3 Microglia & innate immunity 66 26 docs

Matched on CR3 CD11b ITGAM

Often named withAPOE C1QA C3 APP TREM2 SORL1

MMP2 Reelin, synapse & ECM–PNN 66 25 docs

Matched on MMP-?2

Often named withMMP9 APOE ACAN (aggrecan)TREM2 ADAMTS4 BCAN (brevican)

AQP4 Vascular / BBB 64 4 docs

Matched on AQP4

Often named withLRP1 AGER (RAGE)APOE BACE2 CLDN5 IL6

AIFM2 (FSP1) Oxidative stress & ferroptosis 62 4 docs

Matched on FSP1 AIFM2

Often named withALOX15 APOE GPX4 NFE2L2 (NRF2)ACSL4 APP

PP2A Amyloid & Tau core 60 14 docs

Matched on PP2A PPP2CA

Often named withAPOE APP GSK3B PSEN1 CDK5 KL (klotho)

KMO Neuromodulator / circadian / kynurenine 59 6 docs

Matched on KMO

Often named withAPOE IDO1 TREM2 ACAN (aggrecan)APP IL6

PRKN Bioenergetic / mito / NAD 58 12 docs

Matched on PRKN parkin PARK2

Often named withPINK1 APOE APP TREM2 ACAN (aggrecan)C1QA

NGF Trophic / exercise / resilience 56 13 docs

Matched on nerve growth factor NGF

Often named withAPOE APP BDNF MMP9 PSEN1 BACE1

PLCG2 GWAS / LOAD risk 56 11 docs

Matched on PLCG2

Often named withTREM2 ABI3 APOE PSEN1 CD33 MS4A

FNDC5 (irisin) Trophic / exercise / resilience 53 3 docs

Matched on FNDC5 irisin

Often named withAPOE ACAN (aggrecan)BDNF PSEN1 ABI3 APP

SNCA Neurodegeneration overlap 52 13 docs

Matched on SNCA α-synuclein alpha-synuclein α-syn

Often named withAPOE APP TARDBP (TDP-43)ACAN (aggrecan)CD38 PSEN1

TNR (tenascin-R) Reelin, synapse & ECM–PNN 52 24 docs

Matched on tenascin-?R TNR

Often named withACAN (aggrecan)APOE APP MMP9 VCAN (versican)BCAN (brevican)

CLDN5 Vascular / BBB 51 4 docs

Matched on CLDN5 claudin-?5

Often named withAPOE LRP1 AGER (RAGE)AQP4 BACE2 IL6

GSDMD Microglia & innate immunity 51 7 docs

Matched on GSDMD gasdermin

Often named withNLRP3 APP CASP1 PSEN1 PYCARD ACAN (aggrecan)

SIRT1 Bioenergetic / mito / NAD 50 18 docs

Matched on SIRT1

Often named withAPOE APP BACE1 ADAM10 PARP1 PSEN1

FTH1/FTL (ferritin) Oxidative stress & ferroptosis 48 10 docs

Matched on ferritin FTH1 FTL

Often named withAPOE C1QA C3 NLRP3 TREM2 ACAN (aggrecan)

ADAM10 Amyloid & Tau core 47 16 docs

Matched on ADAM10

Often named withAPOE APP BACE1 PSEN1 SIRT1 TREM2

TIMP3 Reelin, synapse & ECM–PNN 47 6 docs

Matched on TIMP-?3

Often named withACAN (aggrecan)APP BCAN (brevican)MMP9 APOE PSEN1

P2RY12 Microglia & innate immunity 46 27 docs

Matched on P2RY12 P2Y12

Often named withAPOE TMEM119 TREM2 APP CX3CR1 ACAN (aggrecan)

PSEN2 Amyloid & Tau core 45 21 docs

Matched on PSEN2 PS2 presenilin[- ]?2

Often named withAPOE PSEN1 APP TARDBP (TDP-43)TREM2 BACE1

CD33 GWAS / LOAD risk 44 9 docs

Matched on CD33

Often named withTREM2 APOE PSEN1 MS4A APP C1QA

ATP synthase (ATP5x) Bioenergetic / mito / NAD 43 5 docs

Matched on ATP5A1 ATP synthase OSCP ATP5PO

Often named withAPP PSEN1 CD38 MTOR PRKAA (AMPK)APOE

ADAMTS4 Reelin, synapse & ECM–PNN 38 17 docs

Matched on ADAMTS-?4

Often named withACAN (aggrecan)MMP9 APOE MMP2 APP TNR (tenascin-R)

HTRA1 Vascular / BBB 38 1 doc

Matched on HTRA1

Often named withABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4 ADAMTS4

NFE2L2 (NRF2) Oxidative stress & ferroptosis 38 9 docs

Matched on NFE2L2 NRF2

Often named withAPP GPX4 MTOR PSEN1 APOE P2RY12

NOTCH3 Vascular / BBB 37 1 doc

Matched on NOTCH3

Often named withABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4 ADAMTS4

TFEB Autophagy / lysosome / clearance 37 14 docs

Matched on TFEB

Often named withV-ATPase (ATP6V)APOE APP PSEN1 MTOR SQSTM1 (p62)

CTSB Autophagy / lysosome / clearance 36 6 docs

Matched on CTSB cathepsin B

Often named withNLRP3 ACAN (aggrecan)APP CASP1 GSDMD PYCARD

SDC (syndecan) Reelin, synapse & ECM–PNN 36 6 docs

Matched on SDC1 SDC2 SDC3 SDC4 syndecan

Often named withAPOE APP PSEN1 RELN ACAN (aggrecan)DAB1

BACE2 Amyloid & Tau core 35 4 docs

Matched on BACE2

Often named withAGER (RAGE)APOE MMP9 PARP1 APP AQP4

DLG4 (PSD-95) Reelin, synapse & ECM–PNN 35 14 docs

Matched on DLG4 PSD-?95

Often named withAPP APOE PSEN1 DAB1 LRP8 (ApoER2)RELN

HDAC2 Epigenetic & senescence 35 2 docs

Matched on HDAC2

Often named withAPOE SIRT1 SIRT6 ABI3 ACAN (aggrecan)ADAM10

CX3CR1 Microglia & innate immunity 34 19 docs

Matched on CX3CR1

Often named withP2RY12 APOE TREM2 ACAN (aggrecan)APP TMEM119

MFSD2A Vascular / BBB 34 5 docs

Matched on MFSD2A

Often named withAPOE LRP1 AGER (RAGE)APP AQP4 BACE1

NAMPT Bioenergetic / mito / NAD 34 5 docs

Matched on NAMPT

Often named withCD38 PARP1 APOE MTOR SIRT3 APP

SOD1 Oxidative stress & ferroptosis 34 7 docs

Matched on SOD1

Often named withAPOE APP TARDBP (TDP-43)BACE1 MMP9 PSEN1

KL (klotho) Trophic / exercise / resilience 33 9 docs

Matched on klotho

Often named withAPOE PP2A ABI3 ADAM10 APP BACE1

EPHB2 Reelin, synapse & ECM–PNN 32 4 docs

Matched on EphB2 EPHB2

Often named withAPP C4 (complement)CR3 LILRB2 PRNP APOE

NLRP1 Microglia & innate immunity 32 3 docs

Matched on NLRP1

Often named withAPP CASP1 CTSB GSDMD NLRP3 PSEN1

ABCA1 GWAS / LOAD risk 30 12 docs

Matched on ABCA1

Often named withAPOE V-ATPase (ATP6V)APP PSEN1 BACE1 SORL1

AGER (RAGE) Vascular / BBB 30 7 docs

Matched on AGER RAGE

Often named withAPOE APP MMP9 TREM2 ACAN (aggrecan)BACE2

MS4A GWAS / LOAD risk 30 7 docs

Matched on MS4A4A MS4A6A MS4A

Often named withCD33 TREM2 APOE PLCG2 PSEN1 ABI3

SARM1 Bioenergetic / mito / NAD 30 7 docs

Matched on SARM1

Often named withPARP1 APP GPX4 PSEN1 ADAMTS4 APOE

TPH2 Neuromodulator / circadian / kynurenine 30 5 docs

Matched on TPH2

Often named withIDO1 ACAN (aggrecan)APOE APP BDNF KMO

ADAMTS5 Reelin, synapse & ECM–PNN 29 9 docs

Matched on ADAMTS-?5

Often named withADAMTS4 ACAN (aggrecan)APOE MMP9 APP NLRP3

VCAN (versican) Reelin, synapse & ECM–PNN 29 19 docs

Matched on VCAN versican

Often named withACAN (aggrecan)BCAN (brevican)MMP9 NCAN (neurocan)TNR (tenascin-R)APOE

VPS35 Autophagy / lysosome / clearance 29 6 docs

Matched on VPS35

Often named withAPOE APP PSEN1 SORL1 BACE1 DAB1

ARNTL (BMAL1) Neuromodulator / circadian / kynurenine 28 10 docs

Matched on BMAL1 ARNTL

Often named withAPOE C1QA C3 CR3 SORL1 BECN1

PRNP Neurodegeneration overlap 28 11 docs

Matched on PRNP prion protein PrP

Often named withAPOE APP PSEN1 RELN C4 (complement)DLG4 (PSD-95)

ABCA7 GWAS / LOAD risk 27 8 docs

Matched on ABCA7

Often named withAPP PSEN1 APOE BACE1 SORL1 TARDBP (TDP-43)

MAPT Amyloid & Tau core 27 6 docs

Matched on MAPT

Often named withAPOE APP CR3 TARDBP (TDP-43)C4 (complement)MMP9

IL6 Microglia & innate immunity 26 13 docs

Matched on IL-?6

Often named withTNF APOE TREM2 MMP9 MTOR APP

KCNC (Kv3) Neuromodulator / circadian / kynurenine 26 6 docs

Matched on Kv3 KCNC1 KCNC3

Often named withACAN (aggrecan)APP C1QA APOE BCAN (brevican)MMP9

DYRK1A Amyloid & Tau core 25 1 doc

Matched on DYRK1A

Often named withACAN (aggrecan)ADAMTS1 ADAMTS4 ADAMTS5 AGER (RAGE)APOE

FYN Amyloid & Tau core 25 7 docs

Matched on Fyn FYN

Often named withAPOE APP PRNP PSEN1 RELN C1QA

SIRT3 Bioenergetic / mito / NAD 25 8 docs

Matched on SIRT3

Often named withAPOE APP CD38 PARP1 PSEN1 SIRT1

QPRT Neuromodulator / circadian / kynurenine 24 2 docs

Matched on QPRT

Often named withAPOE CD38 GRIN2B IDO1 KMO MTOR

SLC2A1 (GLUT1) Vascular / BBB 24 3 docs

Matched on GLUT1 SLC2A1

Often named withAGER (RAGE)APOE AQP4 BACE2 CLDN5 IL6

ACSL4 Oxidative stress & ferroptosis 23 5 docs

Matched on ACSL4

Often named withAPOE ABCA1 ABCA7 APP CR3 PSEN1

CDKN1A (p21) Epigenetic & senescence 23 4 docs

Matched on CDKN1A p21

Often named withACAN (aggrecan)APOE BCAN (brevican)C1QA C4 (complement)CD38

GRN (progranulin) Autophagy / lysosome / clearance 23 3 docs

Matched on progranulin GRN

Often named withAPOE APP CX3CR1 P2RY12 PSEN1 TREM2

SQSTM1 (p62) Autophagy / lysosome / clearance 23 11 docs

Matched on SQSTM1 p62

Often named withAPP PSEN1 APOE MTOR TFEB TREM2

TMEM119 Microglia & innate immunity 23 20 docs

Matched on TMEM119

Often named withP2RY12 APOE SALL1 APP CX3CR1 ACAN (aggrecan)

C9ORF72 Neurodegeneration overlap 22 3 docs

Matched on C9ORF72

Often named withAPOE APP CD38 MMP2 MMP9 SIRT3

GRIN2B Reelin, synapse & ECM–PNN 22 11 docs

Matched on GRIN2B GluN2B NR2B

Often named withAPOE APP RELN PSEN1 BDNF DAB1

ABI3 GWAS / LOAD risk 21 10 docs

Matched on ABI3

Often named withAPOE PLCG2 TREM2 PSEN1 C3 CD33

MAP1LC3B (LC3) Autophagy / lysosome / clearance 21 7 docs

Matched on MAP1LC3B LC3

Often named withAPP APOE PSEN1 TREM2 BACE1 BIN1

MTHFR Trophic / exercise / resilience 21 5 docs

Matched on MTHFR

Often named withAPOE ABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4

TDO2 Neuromodulator / circadian / kynurenine 21 5 docs

Matched on TDO2 TDO

Often named withIDO1 APOE APP KMO MTOR PSEN1

CLU GWAS / LOAD risk 20 8 docs

Matched on clusterin CLU

Often named withAPOE APP PSEN1 TREM2 C1QA C3

NCAN (neurocan) Reelin, synapse & ECM–PNN 20 16 docs

Matched on NCAN neurocan

Often named withACAN (aggrecan)BCAN (brevican)MMP9 VCAN (versican)APOE TNR (tenascin-R)

GBA Neurodegeneration overlap 18 3 docs

Matched on GBA1 GBA

Often named withACAN (aggrecan)APOE APP BACE1 BIN1 C1QA

SALL1 Microglia & innate immunity 18 16 docs

Matched on SALL1

Often named withP2RY12 TMEM119 APOE APP ACAN (aggrecan)CX3CR1

SV2A Reelin, synapse & ECM–PNN 18 7 docs

Matched on SV2A

Often named withAPOE APP C1QA C4 (complement)LILRB2 C3

CDKN2A (p16) Epigenetic & senescence 17 2 docs

Matched on CDKN2A p16INK4a p16

Often named withCD38 CDKN1A (p21)FTH1/FTL (ferritin)LMNB1 MMP2 NLRP3

COL4A1 Vascular / BBB 17 1 doc

Matched on COL4A1

Often named withABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4 ADAMTS4

DNM1L Bioenergetic / mito / NAD 17 9 docs

Matched on DRP1 DNM1L

Often named withAPOE APP NLRP3 PSEN1 BACE1 OPA1

GRIN2A Reelin, synapse & ECM–PNN 17 6 docs

Matched on GRIN2A GluN2A NR2A

Often named withAPOE GRIN2B RELN APP PSEN1 BDNF

LRRK2 Neurodegeneration overlap 17 5 docs

Matched on LRRK2

Often named withAPOE APP BACE1 PARP1 C1QA MMP9

PICALM GWAS / LOAD risk 17 7 docs

Matched on PICALM

Often named withAPOE APP BACE1 BIN1 PSEN1 SORL1

TOMM20 Bioenergetic / mito / NAD 17 7 docs

Matched on TOM20 TOMM20

Often named withAPOE APP PINK1 TOM40 PRKN NLRP3

CSF1R Microglia & innate immunity 16 9 docs

Matched on CSF1R

Often named withAPOE ACAN (aggrecan)MMP2 MMP9 TREM2 ADAMTS4

PRKAA (AMPK) Bioenergetic / mito / NAD 16 8 docs

Matched on AMPK PRKAA1 PRKAA2

Often named withAPP PSEN1 MTOR APOE NFE2L2 (NRF2)NLRP3

TYROBP GWAS / LOAD risk 16 11 docs

Matched on TYROBP DAP12

Often named withTREM2 ACAN (aggrecan)P2RY12 APOE TNR (tenascin-R)CX3CR1

HAPLN1 Reelin, synapse & ECM–PNN 15 8 docs

Matched on HAPLN1

Often named withACAN (aggrecan)TNR (tenascin-R)APP APOE BCAN (brevican)MMP9

IDE Amyloid & Tau core 15 5 docs

Matched on IDE

Often named withAPOE ABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4

TXNIP Microglia & innate immunity 15 9 docs

Matched on TXNIP

Often named withAPOE BACE1 CAT (catalase)PSEN1 TXN ACAN (aggrecan)

MFN2 Bioenergetic / mito / NAD 14 5 docs

Matched on MFN2

Often named withAPOE APP PSEN1 TARDBP (TDP-43)BACE1 PSEN2

OLIG2 Down-syndrome chr21 14 3 docs

Matched on OLIG2

Often named withACAN (aggrecan)ADAMTS4 ADAMTS5 APOE APP BCAN (brevican)

PDGFRB Vascular / BBB 14 2 docs

Matched on PDGFRB PDGFR-?β

Often named withAGER (RAGE)APOE APP AQP4 BACE1 BACE2

TLR4 Microglia & innate immunity 14 9 docs

Matched on TLR4

Often named withNLRP3 PYCARD TNF TREM2 APOE APP

TREX1 Vascular / BBB 14 1 doc

Matched on TREX1

Often named withABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4 ADAMTS4

CGAS Microglia & innate immunity 13 4 docs

Matched on cGAS CGAS

Often named withAPOE PARP1 STING ACAN (aggrecan)APP BIN1

FOXC1 Vascular / BBB 13 1 doc

Matched on FOXC1

Often named withABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4 ADAMTS4

FUS Neurodegeneration overlap 13 3 docs

Matched on FUS

Often named withAPP MMP9 PSEN1 TARDBP (TDP-43)ABCA1 ABCA7

OPTN Neurodegeneration overlap 13 5 docs

Matched on OPTN optineurin

Often named withAPP MTOR PINK1 PRKN PSEN1 SQSTM1 (p62)

CR1 GWAS / LOAD risk 12 3 docs

Matched on CR1

Often named withAPOE BIN1 C1QA C3 CR3 MMP9

CTSD Autophagy / lysosome / clearance 12 5 docs

Matched on CTSD cathepsin D

Often named withAPOE APP TREM2 BACE1 PSEN1 ABCA7

LIMK1 Reelin, synapse & ECM–PNN 12 5 docs

Matched on LIMK1

Often named withAPOE ARHGEF15 (Ephexin5)DAB1 DLG4 (PSD-95)GSK3B LRP8 (ApoER2)

NLRP2 Microglia & innate immunity 12 2 docs

Matched on NLRP2

Often named withAPP CASP1 CTSB GSDMD NLRP1 NLRP3

S100B Reelin, synapse & ECM–PNN 12 1 doc

Matched on S100B S100β

Often named withACAN (aggrecan)ADAMTS1 ADAMTS4 ADAMTS5 AGER (RAGE)APOE

SPI1 GWAS / LOAD risk 12 5 docs

Matched on SPI1 PU\.1

Often named withAPP PSEN1 TREM2 APOE P2RY12 ABCA7

STING Microglia & innate immunity 12 5 docs

Matched on TMEM173 STING

Often named withAPOE PARP1 ACAN (aggrecan)APP BIN1 C1QA

TH (tyrosine hydroxylase) Neuromodulator / circadian / kynurenine 12 5 docs

Matched on tyrosine hydroxylase

Often named withAPOE APP CD38 FTH1/FTL (ferritin)P2RY12 PARP1

BECN1 Autophagy / lysosome / clearance 11 8 docs

Matched on BECN1 Beclin

Often named withAPOE APP BIN1 PSEN1 TFEB V-ATPase (ATP6V)

FOXP3 Microglia & innate immunity 11 2 docs

Matched on FOXP3

Often named withAPOE APP CLDN5 CLU LRP1 PSEN1

IL18 Microglia & innate immunity 11 7 docs

Matched on IL-?18

Often named withNLRP3 APP PSEN1 PYCARD ACAN (aggrecan)APOE

TIMM23 Bioenergetic / mito / NAD 11 3 docs

Matched on TIM23 TIMM23

Often named withAPOE APP HSD17B10 PINK1 TOM40 TOMM20

C5AR1 Microglia & innate immunity 10 5 docs

Matched on C5aR C5AR1

Often named withAPOE NLRP3 TREM2 APP C1QA C3

NMNAT2 Bioenergetic / mito / NAD 10 4 docs

Matched on NMNAT2

Often named withADAMTS4 APP C1QA C3 GPX4 MMP9

VDAC1 Bioenergetic / mito / NAD 10 3 docs

Matched on VDAC1 VDAC

Often named withAPOE APP BACE1 GSK3B HSD17B10 MFN2

ADAMTS1 Reelin, synapse & ECM–PNN 9 4 docs

Matched on ADAMTS-?1

Often named withACAN (aggrecan)ADAMTS4 BCAN (brevican)MMP9 APOE MMP2

CD2AP GWAS / LOAD risk 9 4 docs

Matched on CD2AP

Often named withAPOE APP BACE1 BIN1 PICALM SORL1

DNM2 Autophagy / lysosome / clearance 9 8 docs

Matched on DNM2

Often named withAPOE BIN1 APP ATP synthase (ATP5x)BECN1 CD38

INPP5D GWAS / LOAD risk 9 4 docs

Matched on INPP5D SHIP1

Often named withCD33 MS4A PLCG2 PSEN1 TREM2 ABCA7

LAMP1 Autophagy / lysosome / clearance 9 3 docs

Matched on LAMP-?1

Often named withAPOE BACE1 P2RY12 TREM2 ACAN (aggrecan)CSF1R

PPARGC1A Bioenergetic / mito / NAD 9 1 doc

Matched on PPARGC1A PGC-?1α PGC-?1alpha PGC-?1a

Often named withACAN (aggrecan)APOE APP ATP synthase (ATP5x)BACE1 BIN1

ALOX15 Oxidative stress & ferroptosis 8 5 docs

Matched on ALOX15 15-LOX

Often named withAPOE GPX4 AIFM2 (FSP1)NFE2L2 (NRF2)PSEN1 ACSL4

HAS1/2/3 Reelin, synapse & ECM–PNN 8 4 docs

Matched on HAS1 HAS2 HAS3 hyaluronan synthase

Often named withACAN (aggrecan)ADAMTS4 APOE BCAN (brevican)HAPLN1 MMP2

IGF1 Trophic / exercise / resilience 8 6 docs

Matched on IGF-?1

Often named withAPOE APP PSEN1 ACAN (aggrecan)BCAN (brevican)BDNF

MEF2C GWAS / LOAD risk 8 2 docs

Matched on MEF2C

Often named withABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4 ADAMTS4

OPA1 Bioenergetic / mito / NAD 8 4 docs

Matched on OPA1

Often named withAPOE APP DNM1L PSEN1 SQSTM1 (p62)ACAN (aggrecan)

TRPML1 Autophagy / lysosome / clearance 8 5 docs

Matched on TRPML1 MCOLN1

Often named withTFEB V-ATPase (ATP6V)APP PSEN1 MTOR SQSTM1 (p62)

TXN Oxidative stress & ferroptosis 8 7 docs

Matched on thioredoxin TXN

Often named withTXNIP APOE APP C1QA C3 ACAN (aggrecan)

VPS26 Autophagy / lysosome / clearance 8 4 docs

Matched on VPS26

Often named withAPOE APP PSEN1 SORL1 VPS35 MTOR

CAT (catalase) Oxidative stress & ferroptosis 7 7 docs

Matched on catalase

Often named withAPOE PSEN1 BACE1 TXNIP APP ACAN (aggrecan)

CDK5 Amyloid & Tau core 7 5 docs

Matched on CDK5

Often named withAPOE GSK3B PP2A APP PSEN1 RELN

DBH Neuromodulator / circadian / kynurenine 7 3 docs

Matched on DBH dopamine β-hydroxylase

Often named withACAN (aggrecan)APOE APP BCAN (brevican)CX3CR1 GPX4

ITGAX Microglia & innate immunity 7 6 docs

Matched on ITGAX CD11c

Often named withAPOE P2RY12 SALL1 TMEM119 TREM2 ACAN (aggrecan)

NQO2 Oxidative stress & ferroptosis 7 3 docs

Matched on NQO2

Often named withAPP ATP synthase (ATP5x)PSEN1 CD38 GPX4 MTOR

SIRT6 Bioenergetic / mito / NAD 7 4 docs

Matched on SIRT6

Often named withSIRT1 APOE APP P2RY12 PARP1 PSEN1

SOD2 Oxidative stress & ferroptosis 7 3 docs

Matched on SOD2

Often named withAPP CD38 MTOR NFE2L2 (NRF2)P2RY12 PARP1

SYK Microglia & innate immunity 7 7 docs

Matched on SYK

Often named withMTOR TREM2 TYROBP ACAN (aggrecan)CX3CR1 P2RY12

TFAM Bioenergetic / mito / NAD 7 3 docs

Matched on TFAM

Often named withACAN (aggrecan)APP CX3CR1 MTOR NFE2L2 (NRF2)OPTN

TMEM106B Autophagy / lysosome / clearance 7 1 doc

Matched on TMEM106B

Often named withABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4 ADAMTS4

TP53 (p53) Epigenetic & senescence 7 5 docs

Matched on TP53 p53

Often named withCD38 PARP1 APOE FTH1/FTL (ferritin)MMP2 MTOR

EPHA1 GWAS / LOAD risk 6 3 docs

Matched on EPHA1

Often named withABCA7 APOE APP BACE1 BIN1 CD2AP

IL1B Microglia & innate immunity 6 2 docs

Matched on IL-?1β IL-?1beta IL1B IL-?1b

Often named withAPOE C1QA C3 NLRP3 TNF TREM2

TLR2 Microglia & innate immunity 6 3 docs

Matched on TLR2

Often named withNLRP3 PYCARD TLR4 ACAN (aggrecan)ADAMTS4 ADAMTS5

VPS4A Autophagy / lysosome / clearance 6 5 docs

Matched on VPS4A

Often named withAPOE APP PSEN1 BACE1 MTOR TREM2

GCLC Oxidative stress & ferroptosis 5 3 docs

Matched on GCLC

Often named withACSL4 AIFM2 (FSP1)ALOX15 APOE C1QA C3

ICAM1 Vascular / BBB 5 2 docs

Matched on ICAM-?1

Often named withAGER (RAGE)APOE AQP4 BACE2 CLDN5 CX3CR1

IFNAR1/2 Down-syndrome chr21 5 2 docs

Matched on IFNAR1 IFNAR2 IFNAR

Often named withAPOE APP C1QA C3 CR3 GSK3B

LMNB1 Epigenetic & senescence 5 4 docs

Matched on LMNB1 lamin B1

Often named withACAN (aggrecan)APOE BCAN (brevican)CD38 CDKN1A (p21)CDKN2A (p16)

LPL Microglia & innate immunity 5 5 docs

Matched on LPL

Often named withAPOE NLRP3 TREM2 C1QA C3 CR3

SYNJ1 Down-syndrome chr21 5 1 doc

Matched on SYNJ1

Often named withACAN (aggrecan)ADAMTS1 ADAMTS4 ADAMTS5 AGER (RAGE)APOE

APBB1 Amyloid & Tau core 4 1 doc

Matched on APBB1 Fe65

Often named withADAM10 APOE APP C1QA C3 C4 (complement)

GPX1 Oxidative stress & ferroptosis 4 3 docs

Matched on GPX1

Often named withAIFM2 (FSP1)ALOX15 APOE FTH1/FTL (ferritin)GPX4 NFE2L2 (NRF2)

HMOX1 Oxidative stress & ferroptosis 4 2 docs

Matched on HMOX1 HO-1 heme oxygenase

Often named withAIFM2 (FSP1)ALOX15 APOE FTH1/FTL (ferritin)GPX1 GPX4

NPTX2 Reelin, synapse & ECM–PNN 4 2 docs

Matched on NPTX2 Narp

Often named withACAN (aggrecan)APOE BCAN (brevican)C1QA C4 (complement)DAB1

SPP1 Microglia & innate immunity 4 4 docs

Matched on SPP1 osteopontin

Often named withAPOE APP C1QA C3 C4 (complement)CX3CR1

STAT (1/3/6) Microglia & innate immunity 4 3 docs

Matched on STAT1 STAT3 STAT6

Often named withAPOE TARDBP (TDP-43)ADAM10 APP BDNF GRIN2B

TET1/2/3 Epigenetic & senescence 4 1 doc

Matched on TET1 TET2 TET3

Often named withABI3 ADAM10 APOE APP BACE1 CD33

VEGF Trophic / exercise / resilience 4 3 docs

Matched on VEGF

Often named withLRP1 ABCA1 ACAN (aggrecan)APOE APP AQP4

IAPP Neurodegeneration overlap 3 1 doc

Matched on IAPP amylin

Often named withADAM10 APBB1 APOE APP C1QA C3

IL10 Microglia & innate immunity 3 3 docs

Matched on IL-?10

Often named withAPOE APP C3 CR3 GSK3B TARDBP (TDP-43)

MTNR1A/B Neuromodulator / circadian / kynurenine 3 1 doc

Matched on MTNR1A MTNR1B melatonin receptor

Often named withAPOE ARNTL (BMAL1)

RCAN1 Down-syndrome chr21 3 1 doc

Matched on RCAN1 DSCR1

Often named withACAN (aggrecan)ADAMTS1 ADAMTS4 ADAMTS5 AGER (RAGE)APOE

VCP Neurodegeneration overlap 3 2 docs

Matched on VCP

Often named withADAM10 APOE APP HSD17B10 PINK1 TIMM23

AIM2 Microglia & innate immunity 2 2 docs

Matched on AIM2

Often named withNLRP3 PYCARD TLR4 TREM2 ABCA7 ACSL4

HLA-DRB1 GWAS / LOAD risk 2 1 doc

Matched on HLA-DRB1 HLA-DRB5 HLA-DR

Often named withABI3 ACAN (aggrecan)ADAMTS4 APOE C1QA C3

KEAP1 Oxidative stress & ferroptosis 2 1 doc

Matched on KEAP1

Often named withACSL4 AIFM2 (FSP1)AIM2 ALOX15 APOE C1QA

KYNU Neuromodulator / circadian / kynurenine 2 1 doc

Matched on KYNU

Often named withABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4 ADAMTS4

NMNAT1 Bioenergetic / mito / NAD 1 1 doc

Matched on NMNAT1

Often named withAPOE CD38 MAOA/MAOB NAMPT PARP1 SARM1

SHANK3 Reelin, synapse & ECM–PNN 1 1 doc

Matched on SHANK3

Often named withABCA1 ABCA7 ABI3 ACAN (aggrecan)ACSL4 ADAMTS4

SLC6A2 (NET) Neuromodulator / circadian / kynurenine 1 1 doc

Matched on SLC6A2 norepinephrine transporter

Often named withACAN (aggrecan)APOE APP BCAN (brevican)DAB1 GSK3B

Gene Index

Method