Bacterial exudate-driven neurodegeneration

Bacterial Exudate Driven Neurodegeneration enters the Adult Cognitive Disease corpus through the work of Walter Lukiw (submission 87), and is indexed here as one of the concepts that submission puts to work.

The argument it belongs to

Walter Lukiw's submission is summarised in this corpus as:

Bacteroides fragilis from the GI-tract microbiome secretes highly neurotoxic exudates including BF-LPS and fragilysin that breach the GI-tract and blood-brain barriers, driving NF-kB-mediated pro-inflammatory microRNA upregulation and progressive neurodegeneration characteristic of AD.

Where it sits

The submission scores against the framework's convergence nodes as: neuroimmune interface 9 · transcriptional / epigenetic 7 · endosomal nexus 2 · cytoskeletal collapse 1 · compensatory paradigm 1 · ApoE4 hub 1.

Its declared subject matter: AOAH-deficiency, LPS-neurotoxicity, miRNA-regulation, dietary-fiber-microbiome, microbiome, Bacteroides-fragilis, LPS, neuroinflammation, microRNA, gut-brain-axis, blood-brain-barrier, fragilysin.

Named by the same submission

5 other concepts enter the corpus through the same paper, so they cover adjacent ground: Barrier dysfunction pathology · GI-tract microbiome neurotoxicity · NF-kB-miRNA inflammatory cascade · Acyloxyacyl Hydrolase Neuroprotection · Gut Microbiome Lipid AD Axis.

Assembled from the corpus rather than written: the summary is quoted from the submission that named it; the node scores are read from its dossier. It has not yet been expanded into an article.