Oskar Fischer Prize — Knowledge Base

A structured knowledge base covering 151 Alzheimer's disease hypotheses submitted to the 2022 Oskar Fischer Prize ($4M, 10 winners).

Prize Winners

Gold ($500K): Estela Area-Gomez · Bess Frost · Ralph Nixon · Carlo Abbate

Silver ($400K): Bernd Moosmann · Donald Weaver

Bronze ($300K): Annelise Barron · Gunnar Gouras · Varghese John · Russell Swerdlow

Convergence Nodes (CSC Framework)

Endosomal Nexus — Receptor trafficking & endosomal convergence
Cytoskeletal Collapse — Dendritic spine & cytoskeleton failure
Compensatory Paradigm — Protective responses turned pathological
Neuroimmune Interface — Complement-microglial pruning cascade
APOE4 Hub — Multi-mechanism genetic risk factor
Transcriptional-Epigenetic Dysregulation — Gene expression lock-in

Temporal Stages

Molecular Initiation (Years -30 to -15)
Endosomal Dysregulation (Years -15 to -5)
Cytoskeletal Perturbation (Years -5 to 0)
Neuroimmune Activation (Years 0 to 5)
Network Disintegration (Years 5 to 15)

External Scientists

Key AD researchers whose work supports, extends, or contradicts the prize entrant theories. 81 scientists across all major AD domains.

By domain: Amyloid immunotherapy · Tau biology · Neuroinflammation/microglia · Endolysosomal/autophagy · Lipid/ApoE · Ferroptosis · Infectious hypothesis · Genetics/GWAS · Biomarkers · Synaptic biology · Vascular/BBB · Clinical trials

Browse all external scientists

Browse

Complete Index — full auto-generated catalog of every page (entrants, externals, concepts, nodes, stages)
Statistics — Auto-generated KB metrics
Prize Entrants — 151 researcher articles
External Scientists — 96 external AD researchers
Concepts — Molecular and theoretical concepts

Note: wiki/pathways/ is reserved but not yet populated — molecular pathways currently live inline in concept pages. See ../AGENTS.md for vault schema and conventions.

Tools

Tool	Command
Generate researcher stubs	`python kb/tools/ingest.py scaffold`
Enrich from PubMed data	`python kb/tools/enrich.py <data.json>`
Rebuild catalog + index	`python kb/tools/build_catalog.py`
Health check	`python kb/tools/lint.py`

Status

Karpathy-pattern alignment complete (2026-06-10). Vault now has AGENTS.md (schema), log.md (append-only history), and index.md (complete catalog). Lint is clean: 0 errors, 0 broken wikilinks, 0 orphans. 151 entrants, 96 external scientists, 626 concepts, 7 convergence nodes. 36 entrants reviewed (DeepResearch). CSC grading (Phase 3) and raw paper extraction (Phase 4) remain. ~117 newly-created concept pages are stubs (status: stub) awaiting enrichment.