Which neurons and synapses are destroyed in Alzheimer's disease — how many, in what order, and by which chain. Scrub the disease through its five stations and watch the front of failure cross the brain.
Press play for a guided progression, or step with ← →
The Front of Failurebrainstem → cortex
The Census of the Dying% of baseline lost
The Mechanistic Chainmolecular cascade
converging on
The Staggered Front
Each population’s decline plotted across the disease. The casualties do not fall together — they fall in sequence, and the net is digested before its cell. Hover a stage; click to sync the March.
Staging is schematic; loss values are anchored to published endpoints — German 1992 · Whitehouse 1982 · Gómez-Isla 1996/1997 · West 1994/2004 · Crapser 2020 · Brady & Mufson 1997 · Terry 1991 · Scheff 2006/2007.
Companion to The Cellular Architecture of Collapse · Organic Network Synthesis · AdultCognitiveDisease.com