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Gene Index

Every gene the corpus names, re-scanned across the 769 published pages of this edition. Each entry carries its mention count and links straight to the papers and concept pages that discuss it — search a symbol or alias, or filter by cluster.

200
Genes
9,063
Mentions
769
Pages scanned
13
Clusters
RELN Reelin, synapse & ECM–PNN 948 14 docs
Matched on RELN reelin
Often named withAPOEDAB1LRP8 (ApoER2)PSEN1VLDLRAPP
  1. The Architect's Reprievepaper265
  2. The Coerulean Shearspaper187
  3. The Architect's Handshakepaper162
  4. The Architect's Scaffoldpaper104
  5. The Coerulean Pincerpaper85
  6. Reelin-ApoE receptor axis disruptionconcept43
  7. The Unified Architecture of Collapsepaper25
  8. The Architecture of Resistancepaper20
  9. Matrix Sulfation Nodeconcept16
  10. The Genetic Architecture of Neurodegenerationpaper16
  11. Perineuronal Netsconcept13
  12. APOE4 Hubnode7
  13. The Silenced Eraserpaper4
  14. The Cellular Architecture of Collapsepaper1
APOE Amyloid & Tau core 852 82 docs
Matched on apoe[234]? apo[- ]?E[234]? apolipoprotein E
Often named withAPPPSEN1TREM2V-ATPase (ATP6V)MMP9ACAN (aggrecan)
  1. The Genetic Architecture of Neurodegenerationpaper102
  2. The Narrow Gatepaper97
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper77
  4. The Vascular Phasingpaper65
  5. The Architecture of Resistancepaper56
  6. The Vascular Dimensionpaper47
  7. The Viral Trajectorypaper45
  8. The Architect's Reprievepaper34
  9. The Architect's Handshakepaper29
  10. Reelin-ApoE receptor axis disruptionconcept22
  11. The Corruption of the Gardenerpaper21
  12. The Unified Architecture of Collapsepaper15
  13. PARP Inhibitors and the Locus Coeruleuspaper14
  14. TOMM40 Import Gateconcept12
  15. APOE4 Hubnode11
  16. Iron Chelation and GPX4 Stabilizationpaper10
  17. The Janus Lipidpaper9
  18. Cholesterol Homeostasisconcept8
  19. Lipid Metabolismconcept8
  20. Endosomal Traffickingconcept7
  21. Lipid Peroxidationconcept7
  22. The Silenced Eraserpaper7
  23. Matrix Sulfation Nodeconcept6
  24. The Architect's Scaffoldpaper6
  25. The Coerulean Pincerpaper6
  26. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper5
  27. The Coerulean Shearspaper5
  28. The Mitochondrion as Nexuspaper5
  29. The Temporal Architecture of Collapsepaper5
  30. Viral Pathogenesisconcept5
  31. Endosomal Nexusnode4
  32. Innate Immunityconcept4
  33. The DAM Trajectory and the Matrix-degrading Armpaper4
  34. The Muscle's Errandpaper4
  35. Ferroptosis and the Phase II Oligodendrocyte Crisispaper3
  36. Inside Out Plaqueconcept3
  37. Intracellular Amyloidconcept3
  38. Lysosomal Acidificationconcept3
  39. The Case for the Cascadepaper3
  40. The Complement-pruning Substratepaper3
  41. The Locus Coeruleus Bridgepaper3
  42. The Matrix of Collapsepaper3
  43. The Proteolytic Turnpaper3
  44. The Tide-gatepaper3
  45. ApoE isoform-heparin binding differencesconcept2
  46. ApoE-centric unified modelconcept2
  47. APOE4 Endolysosomal Dysfunctionconcept2
  48. APOE4 Pathogen Interactionconcept2
  49. ApoE4 structural vulnerabilityconcept2
  50. Autophagic Collapseconcept2
  51. Autophagyconcept2
  52. Convergent Synaptic Collapse (CSC) — Grading Referencepaper2
  53. Dietary Fatty Acid APOE4 Rescueconcept2
  54. Ferroptosisconcept2
  55. Gut Brain Axisconcept2
  56. Mitochondrial Dysfunctionconcept2
  57. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper2
  58. Oxidative Stressconcept2
  59. Peroxidized ApoE as proximate causeconcept2
  60. Ramsdenpaper2
  61. Synaptic Pathologyconcept2
  62. The Adult-born Neuronpaper2
  63. The Cellular Architecture of Collapsepaper2
  64. The Clearance Collapsepaper2
  65. The Pineal Interfacepaper2
  66. The Pv+/gamma Axispaper2
  67. Calcium Homeostasisconcept1
  68. Margolispaper1
  69. Neuroimmune Interfacenode1
  70. Neuroinflammationconcept1
  71. Perineuronal Netsconcept1
  72. The Biomarker Cascadepaper1
  73. The Compressed Architecturepaper1
  74. The Depression Continuumpaper1
  75. The Energy-gated Tauopathypaper1
  76. The Fading Scorepaper1
  77. The Immunometabolic Checkpointpaper1
  78. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper1
  79. The Senescent Frontpaper1
  80. The Trojan Neuroblastpaper1
  81. The Tryptophan Partitionpaper1
  82. The Wax and the Weldpaper1
NLRP3 Microglia & innate immunity 371 29 docs
Matched on NLRP3
Often named withAPOEAPPTREM2PSEN1C3C1QA
  1. The Sensor and the Speckpaper93
  2. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper41
  3. One Sensor, Two Collapsespaper36
  4. The Mitochondrion as Nexuspaper35
  5. The Net and the Speckpaper32
  6. The Ketamine Paradoxpaper27
  7. The Silenced Eraserpaper22
  8. The Depression Continuumpaper20
  9. The Corruption of the Gardenerpaper14
  10. The Proteolytic Turnpaper11
  11. The Clearance Collapsepaper7
  12. The Spectrum of Collapsepaper7
  13. The Temporal Architecture of Collapsepaper6
  14. Neuroinflammationconcept2
  15. The Complement-pruning Substratepaper2
  16. The Compressed Architecturepaper2
  17. The Unified Architecture of Collapsepaper2
  18. Autophagyconcept1
  19. Bioenergetic Collapsepaper1
  20. Cellular Senescenceconcept1
  21. Cholesterol Homeostasisconcept1
  22. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  23. Innate Immunityconcept1
  24. The Cellular Architecture of Collapsepaper1
  25. The DAM Trajectory and the Matrix-degrading Armpaper1
  26. The Pv+/gamma Axispaper1
  27. The Restorative Intervalpaper1
  28. The Senescent Frontpaper1
  29. When the Brain's Immune Cells Turn Toxicpaper1
MMP9 Reelin, synapse & ECM–PNN 347 27 docs
Matched on MMP-?9
Often named withAPOEACAN (aggrecan)APPBCAN (brevican)MMP2C1QA
  1. The Coerulean Shearspaper92
  2. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper88
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper30
  4. The DAM Trajectory and the Matrix-degrading Armpaper20
  5. The Genetic Architecture of Neurodegenerationpaper20
  6. The Proteolytic Turnpaper18
  7. The Vascular Phasingpaper15
  8. The Viral Trajectorypaper11
  9. The Gamma Interventionpaper6
  10. The Vascular Dimensionpaper6
  11. The Matrix of Collapsepaper5
  12. The Net and the Speckpaper5
  13. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper4
  14. The Adult-born Neuronpaper3
  15. The Coerulean Pincerpaper3
  16. The Compressed Architecturepaper3
  17. The Depression Continuumpaper3
  18. The Temporal Architecture of Collapsepaper3
  19. Perineuronal Netsconcept2
  20. The Locus Coeruleus Bridgepaper2
  21. The Senescent Frontpaper2
  22. Fischer's Sideliningpaper1
  23. The Cellular Architecture of Collapsepaper1
  24. The Complement-pruning Substratepaper1
  25. The Pv+/gamma Axispaper1
  26. The Spectrum of Collapsepaper1
  27. The Unified Architecture of Collapsepaper1
CD38 Bioenergetic / mito / NAD 338 17 docs
Matched on CD38
Often named withAPOEPARP1TREM2APPMTORMMP2
  1. NAD⁺ Restoration and CD38 Inhibitionpaper113
  2. The Immunometabolic Checkpointpaper59
  3. The Mitochondrion as Nexuspaper36
  4. PARP Inhibitors and the Locus Coeruleuspaper22
  5. The Viral Trajectorypaper19
  6. The Senescent Frontpaper18
  7. The Tryptophan Partitionpaper12
  8. Iron Chelation and GPX4 Stabilizationpaper10
  9. The Genetic Architecture of Neurodegenerationpaper10
  10. Cellular Senescenceconcept9
  11. The Unified Architecture of Collapsepaper9
  12. The Clearance Collapsepaper7
  13. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper6
  14. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  15. The DAM Trajectory and the Matrix-degrading Armpaper3
  16. The Peripheral Arm of Homeostatic Collapsepaper1
  17. The Pv+/gamma Axispaper1
TREM2 GWAS / LOAD risk 313 31 docs
Matched on s?TREM2
Often named withAPOEAPPNLRP3C1QAC3MMP9
  1. The Genetic Architecture of Neurodegenerationpaper58
  2. The Biomarker Cascadepaper56
  3. The Architecture of Resistancepaper33
  4. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper29
  5. The Corruption of the Gardenerpaper28
  6. The DAM Trajectory and the Matrix-degrading Armpaper11
  7. The Temporal Architecture of Collapsepaper10
  8. The Silenced Eraserpaper9
  9. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper8
  10. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper8
  11. The Unified Architecture of Collapsepaper7
  12. The Clearance Collapsepaper6
  13. The Mitochondrion as Nexuspaper6
  14. Metabolic-Homeostatic Axisnode5
  15. The Cellular Architecture of Collapsepaper5
  16. The Sensor and the Speckpaper5
  17. Ferroptosis and the Phase II Oligodendrocyte Crisispaper4
  18. Neuroinflammationconcept4
  19. The Viral Trajectorypaper4
  20. Bioenergeticsconcept2
  21. Convergent Synaptic Collapse (CSC) — Grading Referencepaper2
  22. Neuroimmune Interfacenode2
  23. The Tryptophan Partitionpaper2
  24. The Vascular Phasingpaper2
  25. Innate Immunityconcept1
  26. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper1
  27. Perineuronal Netsconcept1
  28. The Complement-pruning Substratepaper1
  29. The Depression Continuumpaper1
  30. The Peripheral Arm of Homeostatic Collapsepaper1
  31. The Proteolytic Turnpaper1
APP Amyloid & Tau core 310 61 docs
Matched on amyloid precursor protein APP
Often named withAPOEPSEN1MMP9V-ATPase (ATP6V)ACAN (aggrecan)NLRP3
  1. The Compressed Architecturepaper56
  2. The Mitochondrion as Nexuspaper26
  3. The Narrow Gatepaper22
  4. The Case for the Cascadepaper18
  5. The Genetic Architecture of Neurodegenerationpaper18
  6. The Architecture of Resistancepaper16
  7. The Wax and the Weldpaper12
  8. The Trojan Neuroblastpaper10
  9. Iron Chelation and GPX4 Stabilizationpaper9
  10. The Janus Lipidpaper8
  11. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper7
  12. Endosomal Traffickingconcept6
  13. The Spectrum of Collapsepaper6
  14. The Unified Architecture of Collapsepaper6
  15. Plaque Origin What is Establishedconcept5
  16. The Architect's Reprievepaper4
  17. The Viral Trajectorypaper4
  18. TOMM40 Import Gateconcept4
  19. Endosomal Nexusnode3
  20. Fischer's Sideliningpaper3
  21. The Architect's Handshakepaper3
  22. The Sensor and the Speckpaper3
  23. The Temporal Architecture of Collapsepaper3
  24. AD caused by APP dysregulation not Abeta per seconcept2
  25. APP and tau pathology linked through transport disruptionconcept2
  26. APP as dependence receptorconcept2
  27. APP processing pathwayconcept2
  28. Autophagyconcept2
  29. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper2
  30. Ferroptosisconcept2
  31. Gene dosage of APP directly causes pathogenesisconcept2
  32. Lipid Metabolismconcept2
  33. Lysosomal Acidificationconcept2
  34. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper2
  35. Need to understand normal APP functionconcept2
  36. One Sensor, Two Collapsespaper2
  37. The Clearance Collapsepaper2
  38. The Coerulean Interfacepaper2
  39. The Corruption of the Gardenerpaper2
  40. The Depression Continuumpaper2
  41. The Gamma Interventionpaper2
  42. The Ketamine Paradoxpaper2
  43. The Peacekeeper's Paradoxpaper2
  44. AG18051 and the Aβ–ABAD Complexpaper1
  45. Axonal Transportconcept1
  46. Cholesterol Homeostasisconcept1
  47. Convergent Synaptic Collapse (CSC) — Grading Referencepaper1
  48. Mitochondrial Dysfunctionconcept1
  49. NAD⁺ Restoration and CD38 Inhibitionpaper1
  50. Oxidative Stressconcept1
  51. PANTHOSconcept1
  52. The Adult-born Neuronpaper1
  53. The Architect's Scaffoldpaper1
  54. The Cellular Architecture of Collapsepaper1
  55. The Coerulean Pincerpaper1
  56. The Coerulean Shearspaper1
  57. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper1
  58. The Locus Coeruleus Bridgepaper1
  59. The Restorative Intervalpaper1
  60. The Silenced Eraserpaper1
  61. The Vascular Dimensionpaper1
BDNF Trophic / exercise / resilience 251 7 docs
Matched on BDNF
Often named withAPOEAPPPARP1PSEN1MMP9MTOR
  1. The Withdrawn Subsidypaper181
  2. The Depression Continuumpaper29
  3. The Tryptophan Partitionpaper16
  4. The Ketamine Paradoxpaper11
  5. The Muscle's Errandpaper8
  6. The Adult-born Neuronpaper5
  7. The Spectrum of Collapsepaper1
HSD17B10 Bioenergetic / mito / NAD 241 4 docs
Matched on HSD17B10 HSD10 ABAD 17β-HSD10 17beta-HSD10
Often named withAPPAPOEPINK1TIMM23TOM40TOMM20
  1. AG18051 and the Aβ–ABAD Complexpaper184
  2. The Narrow Gatepaper34
  3. TOMM40 Import Gateconcept12
  4. The Mitochondrion as Nexuspaper11
VCAM1 Vascular / BBB 194 5 docs
Matched on VCAM-?1
Often named withPARP1APOELRP1MMP9TNFAGER (RAGE)
  1. The Vascular Phasingpaper75
  2. The Vascular Dimensionpaper67
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper48
  4. The Temporal Architecture of Collapsepaper3
  5. The Vagal Interfacepaper1
GPX4 Oxidative stress & ferroptosis 182 14 docs
Matched on GPX4
Often named withAPOEAPPPSEN1PARP1MTORNFE2L2 (NRF2)
  1. Iron Chelation and GPX4 Stabilizationpaper85
  2. Ferroptosis and the Phase II Oligodendrocyte Crisispaper53
  3. NAD⁺ Restoration and CD38 Inhibitionpaper9
  4. Ferroptosisconcept6
  5. The Genetic Architecture of Neurodegenerationpaper6
  6. Lipid Peroxidationconcept4
  7. The Locus Coeruleus Bridgepaper4
  8. The Spectrum of Collapsepaper4
  9. Oxidative Stressconcept3
  10. The Ketamine Paradoxpaper3
  11. The Clearance Collapsepaper2
  12. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  13. The Proteolytic Turnpaper1
  14. The Temporal Architecture of Collapsepaper1
PARP1 Bioenergetic / mito / NAD 174 23 docs
Matched on PARP-?1 PARP1
Often named withAPOEAPPMMP9ACAN (aggrecan)CD38P2RY12
  1. PARP Inhibitors and the Locus Coeruleuspaper81
  2. NAD⁺ Restoration and CD38 Inhibitionpaper13
  3. The Tryptophan Partitionpaper13
  4. The Immunometabolic Checkpointpaper7
  5. The Spectrum of Collapsepaper7
  6. The Vascular Phasingpaper7
  7. The Viral Trajectorypaper7
  8. The Genetic Architecture of Neurodegenerationpaper6
  9. The Senescent Frontpaper6
  10. The Temporal Architecture of Collapsepaper5
  11. The Locus Coeruleus Bridgepaper4
  12. The Unified Architecture of Collapsepaper3
  13. The Adult-born Neuronpaper2
  14. The Clearance Collapsepaper2
  15. The Ketamine Paradoxpaper2
  16. The Vascular Dimensionpaper2
  17. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  18. The Cellular Architecture of Collapsepaper1
  19. The Compressed Architecturepaper1
  20. The Energy-gated Tauopathypaper1
  21. The Fading Scorepaper1
  22. The Mitochondrion as Nexuspaper1
  23. The Vagal Interfacepaper1
ACAN (aggrecan) Reelin, synapse & ECM–PNN 154 25 docs
Matched on ACAN aggrecan
Often named withAPOEBCAN (brevican)MMP9APPTNR (tenascin-R)PSEN1
  1. The Net and the Speckpaper26
  2. The Perineuronal Turnpaper15
  3. The Matrix of Collapsepaper13
  4. The Proteolytic Turnpaper12
  5. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper9
  6. One Sensor, Two Collapsespaper9
  7. The Architect's Scaffoldpaper9
  8. The Genetic Architecture of Neurodegenerationpaper9
  9. The Temporal Architecture of Collapsepaper9
  10. The Coerulean Shearspaper6
  11. The Compressed Architecturepaper6
  12. Perineuronal Netsconcept5
  13. The Unified Architecture of Collapsepaper5
  14. The Cellular Architecture of Collapsepaper4
  15. The Coerulean Pincerpaper3
  16. The Architect's Reprievepaper2
  17. The Biomarker Cascadepaper2
  18. The Depression Continuumpaper2
  19. The Gamma Interventionpaper2
  20. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  21. The Adult-born Neuronpaper1
  22. The Fading Scorepaper1
  23. The Locus Coeruleus Bridgepaper1
  24. The Mitochondrion as Nexuspaper1
  25. The Senescent Frontpaper1
IDO1 Neuromodulator / circadian / kynurenine 147 8 docs
Matched on IDO1 IDO
Often named withAPOEIL6TNFTREM2APPCD38
  1. The Tryptophan Partitionpaper92
  2. The Depression Continuumpaper23
  3. The Viral Trajectorypaper21
  4. The Biomarker Cascadepaper7
  5. NAD⁺ Restoration and CD38 Inhibitionpaper1
  6. The Coerulean Interfacepaper1
  7. The DAM Trajectory and the Matrix-degrading Armpaper1
  8. The Genetic Architecture of Neurodegenerationpaper1
LRP8 (ApoER2) Reelin, synapse & ECM–PNN 146 21 docs
Matched on LRP8 ApoER2 APOER2
Often named withAPOEDAB1PSEN1APPRELNVLDLR
  1. The Coerulean Shearspaper35
  2. The Architect's Handshakepaper30
  3. The Architect's Reprievepaper17
  4. The Coerulean Pincerpaper13
  5. Iron Chelation and GPX4 Stabilizationpaper11
  6. Reelin-ApoE receptor axis disruptionconcept10
  7. The Architect's Scaffoldpaper4
  8. Lipid Peroxidationconcept3
  9. The Genetic Architecture of Neurodegenerationpaper3
  10. The Matrix of Collapsepaper3
  11. The Unified Architecture of Collapsepaper3
  12. APOE4 Hubnode2
  13. Convergent Synaptic Collapse (CSC) — Grading Referencepaper2
  14. Endosomal Nexusnode2
  15. Ferroptosisconcept2
  16. Cholesterol Homeostasisconcept1
  17. Matrix Sulfation Nodeconcept1
  18. Perineuronal Netsconcept1
  19. Ramsdenpaper1
  20. The Architecture of Resistancepaper1
  21. The Temporal Architecture of Collapsepaper1
V-ATPase (ATP6V) Autophagy / lysosome / clearance 142 33 docs
Matched on V-ATPase ATP6V vacuolar[- ]?(?:type )?ATPase
Often named withAPOEAPPPSEN1TREM2MTORSORL1
  1. Lysosomal Acidificationconcept21
  2. The Pv+/gamma Axispaper15
  3. The Mitochondrion as Nexuspaper12
  4. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper8
  5. The Clearance Collapsepaper8
  6. Bioenergeticsconcept7
  7. The Trojan Neuroblastpaper7
  8. Autophagyconcept6
  9. Calcium Homeostasisconcept6
  10. Cholesterol Homeostasisconcept5
  11. Ferroptosisconcept5
  12. The Genetic Architecture of Neurodegenerationpaper5
  13. Mitochondrial Dysfunctionconcept4
  14. Endosomal Traffickingconcept3
  15. Lipid Metabolismconcept3
  16. Lipid Peroxidationconcept3
  17. Autophagic Collapseconcept2
  18. Endosomal Nexusnode2
  19. Gut Brain Axisconcept2
  20. Neuroinflammationconcept2
  21. Oxidative Stressconcept2
  22. The Biomarker Cascadepaper2
  23. Viral Pathogenesisconcept2
  24. Convergent Synaptic Collapse (CSC) — Grading Referencepaper1
  25. Fischer's Sideliningpaper1
  26. How Plaques Actually Formpaper1
  27. Khachaturianpaper1
  28. Metabolic-Homeostatic Axisnode1
  29. Iron Chelation and GPX4 Stabilizationpaper1
  30. The Bioenergetic Thesis (Downloadable PDF)paper1
  31. The Tryptophan Partitionpaper1
  32. TOMM40 Import Gateconcept1
  33. Why the Cell's Recycling System Breakspaper1
DAB1 Reelin, synapse & ECM–PNN 128 17 docs
Matched on DAB1 Disabled-1
Often named withAPOELRP8 (ApoER2)PSEN1RELNAPPVLDLR
  1. The Coerulean Shearspaper26
  2. The Architect's Handshakepaper25
  3. The Architect's Reprievepaper20
  4. The Coerulean Pincerpaper18
  5. The Architect's Scaffoldpaper11
  6. Reelin-ApoE receptor axis disruptionconcept8
  7. The Matrix of Collapsepaper3
  8. The Unified Architecture of Collapsepaper3
  9. Convergent Synaptic Collapse (CSC) — Grading Referencepaper2
  10. Endosomal Nexusnode2
  11. Perineuronal Netsconcept2
  12. The Architecture of Resistancepaper2
  13. The Genetic Architecture of Neurodegenerationpaper2
  14. APOE4 Hubnode1
  15. Lipid Peroxidationconcept1
  16. Matrix Sulfation Nodeconcept1
  17. The Temporal Architecture of Collapsepaper1
TOMM40 Bioenergetic / mito / NAD 127 5 docs
Matched on TOMM40
Often named withAPOEAPPTOM40HSD17B10PINK1TIMM23
  1. The Narrow Gatepaper99
  2. TOMM40 Import Gateconcept14
  3. The Mitochondrion as Nexuspaper9
  4. Mitochondrial Dysfunctionconcept3
  5. APOE4 Hubnode2
PSEN1 Amyloid & Tau core 108 45 docs
Matched on PSEN1 PS1 presenilin[- ]?1
Often named withAPPAPOELRP8 (ApoER2)NLRP3ACAN (aggrecan)V-ATPase (ATP6V)
  1. The Genetic Architecture of Neurodegenerationpaper19
  2. Iron Chelation and GPX4 Stabilizationpaper15
  3. The Mitochondrion as Nexuspaper11
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper4
  5. The Architect's Reprievepaper4
  6. The Sensor and the Speckpaper3
  7. Calcium Homeostasisconcept2
  8. Ferroptosisconcept2
  9. Lysosomal Acidificationconcept2
  10. One Sensor, Two Collapsespaper2
  11. The Architecture of Resistancepaper2
  12. The Case for the Cascadepaper2
  13. The Clearance Collapsepaper2
  14. The Corruption of the Gardenerpaper2
  15. The Depression Continuumpaper2
  16. The Gamma Interventionpaper2
  17. The Ketamine Paradoxpaper2
  18. The Peacekeeper's Paradoxpaper2
  19. The Wax and the Weldpaper2
  20. AG18051 and the Aβ–ABAD Complexpaper1
  21. APOE4 Hubnode1
  22. Autophagic Collapseconcept1
  23. Autophagyconcept1
  24. Endosomal Nexusnode1
  25. Fischer's Sideliningpaper1
  26. Lipid Metabolismconcept1
  27. Lipid Peroxidationconcept1
  28. NAD⁺ Restoration and CD38 Inhibitionpaper1
  29. Reelin-ApoE receptor axis disruptionconcept1
  30. Synaptic Pathologyconcept1
  31. The Adult-born Neuronpaper1
  32. The Architect's Handshakepaper1
  33. The Architect's Scaffoldpaper1
  34. The Coerulean Interfacepaper1
  35. The Coerulean Pincerpaper1
  36. The Coerulean Shearspaper1
  37. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper1
  38. The Janus Lipidpaper1
  39. The Locus Coeruleus Bridgepaper1
  40. The Pv+/gamma Axispaper1
  41. The Restorative Intervalpaper1
  42. The Silenced Eraserpaper1
  43. The Spectrum of Collapsepaper1
  44. The Temporal Architecture of Collapsepaper1
  45. The Unified Architecture of Collapsepaper1
PYCARD Microglia & innate immunity 93 9 docs
Matched on PYCARD ASC
Often named withNLRP3CASP1APPPSEN1TLR4TREM2
  1. The Sensor and the Speckpaper53
  2. One Sensor, Two Collapsespaper16
  3. The Mitochondrion as Nexuspaper7
  4. The Silenced Eraserpaper5
  5. The Net and the Speckpaper4
  6. The Corruption of the Gardenerpaper3
  7. The Ketamine Paradoxpaper3
  8. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  9. The Depression Continuumpaper1
TOM40 Bioenergetic / mito / NAD 85 8 docs
Matched on TOM40
Often named withAPOEAPPPINK1PRKNTOMM20NLRP3
  1. The Narrow Gatepaper53
  2. The Mitochondrion as Nexuspaper16
  3. TOMM40 Import Gateconcept5
  4. The Clearance Collapsepaper4
  5. The Unified Architecture of Collapsepaper4
  6. Mitochondrial Dysfunctionconcept1
  7. The Cellular Architecture of Collapsepaper1
  8. The Temporal Architecture of Collapsepaper1
MTOR Autophagy / lysosome / clearance 83 15 docs
Matched on mTOR MTOR mTORC1 mTORC2
Often named withTREM2APOEAPPPSEN1CD38PARP1
  1. The Ketamine Paradoxpaper26
  2. The Clearance Collapsepaper18
  3. The Depression Continuumpaper17
  4. Metabolic-Homeostatic Axisnode5
  5. The Mitochondrion as Nexuspaper4
  6. Bioenergeticsconcept2
  7. The Biomarker Cascadepaper2
  8. The Genetic Architecture of Neurodegenerationpaper2
  9. Cellular Senescenceconcept1
  10. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  11. Iron Chelation and GPX4 Stabilizationpaper1
  12. NAD⁺ Restoration and CD38 Inhibitionpaper1
  13. The Temporal Architecture of Collapsepaper1
  14. The Tryptophan Partitionpaper1
  15. The Unified Architecture of Collapsepaper1
C1QA Microglia & innate immunity 82 21 docs
Matched on C1q C1QA C1QB
Often named withC3APOETREM2MMP9APPCR3
  1. The Complement-pruning Substratepaper18
  2. The Proteolytic Turnpaper17
  3. The Genetic Architecture of Neurodegenerationpaper10
  4. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper6
  5. The Temporal Architecture of Collapsepaper4
  6. The Cellular Architecture of Collapsepaper3
  7. The Unified Architecture of Collapsepaper3
  8. The Viral Trajectorypaper3
  9. Ferroptosis and the Phase II Oligodendrocyte Crisispaper2
  10. The Compressed Architecturepaper2
  11. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper2
  12. The Mitochondrion as Nexuspaper2
  13. The Senescent Frontpaper2
  14. Convergent Synaptic Collapse (CSC) — Grading Referencepaper1
  15. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  16. Neuroimmune Interfacenode1
  17. Neuroinflammationconcept1
  18. Synaptic Pathologyconcept1
  19. The Gamma Interventionpaper1
  20. The Matrix of Collapsepaper1
  21. The Spectrum of Collapsepaper1
BCAN (brevican) Reelin, synapse & ECM–PNN 68 20 docs
Matched on BCAN brevican
Often named withACAN (aggrecan)MMP9APOEAPPNCAN (neurocan)VCAN (versican)
  1. The Proteolytic Turnpaper12
  2. The Genetic Architecture of Neurodegenerationpaper8
  3. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper7
  4. The Temporal Architecture of Collapsepaper6
  5. The Coerulean Shearspaper5
  6. The Coerulean Pincerpaper4
  7. Perineuronal Netsconcept3
  8. The Cellular Architecture of Collapsepaper3
  9. The Matrix of Collapsepaper3
  10. The Net and the Speckpaper3
  11. The Compressed Architecturepaper2
  12. The Depression Continuumpaper2
  13. The Perineuronal Turnpaper2
  14. The Unified Architecture of Collapsepaper2
  15. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  16. The Adult-born Neuronpaper1
  17. The Fading Scorepaper1
  18. The Gamma Interventionpaper1
  19. The Locus Coeruleus Bridgepaper1
  20. The Senescent Frontpaper1
PINK1 Bioenergetic / mito / NAD 66 11 docs
Matched on PINK1
Often named withAPOEPRKNAPPC1QAC3PARP1
  1. The Mitochondrion as Nexuspaper17
  2. The Narrow Gatepaper17
  3. The Genetic Architecture of Neurodegenerationpaper14
  4. TOMM40 Import Gateconcept6
  5. The Clearance Collapsepaper3
  6. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  7. The Cellular Architecture of Collapsepaper2
  8. The Temporal Architecture of Collapsepaper2
  9. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  10. The Senescent Frontpaper1
  11. The Unified Architecture of Collapsepaper1
AQP4 Vascular / BBB 64 4 docs
Matched on AQP4
Often named withLRP1AGER (RAGE)APOEBACE2CLDN5IL6
  1. The Glymphatic Collapsepaper30
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper18
  3. The Vascular Dimensionpaper9
  4. The Vascular Phasingpaper7
AIFM2 (FSP1) Oxidative stress & ferroptosis 62 4 docs
Matched on FSP1 AIFM2
Often named withALOX15APOEGPX4NFE2L2 (NRF2)ACSL4APP
  1. Iron Chelation and GPX4 Stabilizationpaper34
  2. Ferroptosis and the Phase II Oligodendrocyte Crisispaper20
  3. The Genetic Architecture of Neurodegenerationpaper7
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
CASP1 Microglia & innate immunity 62 11 docs
Matched on CASP1 caspase[- ]?1
Often named withNLRP3APPPSEN1PYCARDTREM2ACAN (aggrecan)
  1. The Sensor and the Speckpaper30
  2. The Net and the Speckpaper10
  3. One Sensor, Two Collapsespaper9
  4. The Silenced Eraserpaper4
  5. The Corruption of the Gardenerpaper2
  6. The Ketamine Paradoxpaper2
  7. The Depression Continuumpaper1
  8. The Mitochondrion as Nexuspaper1
  9. The Proteolytic Turnpaper1
  10. The Temporal Architecture of Collapsepaper1
  11. The Unified Architecture of Collapsepaper1
MMP2 Reelin, synapse & ECM–PNN 55 16 docs
Matched on MMP-?2
Often named withMMP9APOEACAN (aggrecan)BCAN (brevican)NCAN (neurocan)TREM2
  1. The DAM Trajectory and the Matrix-degrading Armpaper24
  2. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper8
  3. The Genetic Architecture of Neurodegenerationpaper4
  4. Cellular Senescenceconcept3
  5. The Coerulean Shearspaper3
  6. Perineuronal Netsconcept2
  7. The Net and the Speckpaper2
  8. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
  9. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  10. The Coerulean Pincerpaper1
  11. The Proteolytic Turnpaper1
  12. The Pv+/gamma Axispaper1
  13. The Senescent Frontpaper1
  14. The Spectrum of Collapsepaper1
  15. The Unified Architecture of Collapsepaper1
  16. The Vascular Phasingpaper1
BACE1 Amyloid & Tau core 52 16 docs
Matched on BACE1
Often named withAPOEAPPPSEN1V-ATPase (ATP6V)SORL1TREM2
  1. The Architecture of Resistancepaper14
  2. The Janus Lipidpaper13
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper4
  4. The Vascular Dimensionpaper4
  5. Endosomal Traffickingconcept3
  6. The Wax and the Weldpaper3
  7. The Genetic Architecture of Neurodegenerationpaper2
  8. Axonal Transportconcept1
  9. Cholesterol Homeostasisconcept1
  10. Convergent Synaptic Collapse (CSC) — Grading Referencepaper1
  11. Endosomal Nexusnode1
  12. Innate Immunityconcept1
  13. Lipid Metabolismconcept1
  14. The Mitochondrion as Nexuspaper1
  15. The Narrow Gatepaper1
  16. The Withdrawn Subsidypaper1
C3 Microglia & innate immunity 52 21 docs
Matched on C3
Often named withC1QAAPOETREM2APPCR3MMP9
  1. The Complement-pruning Substratepaper12
  2. The Genetic Architecture of Neurodegenerationpaper7
  3. The Spectrum of Collapsepaper5
  4. The Proteolytic Turnpaper4
  5. Ferroptosis and the Phase II Oligodendrocyte Crisispaper2
  6. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper2
  7. The Cellular Architecture of Collapsepaper2
  8. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper2
  9. The Temporal Architecture of Collapsepaper2
  10. The Unified Architecture of Collapsepaper2
  11. The Viral Trajectorypaper2
  12. Convergent Synaptic Collapse (CSC) — Grading Referencepaper1
  13. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  14. Neuroimmune Interfacenode1
  15. Neuroinflammationconcept1
  16. Synaptic Pathologyconcept1
  17. The Compressed Architecturepaper1
  18. The Gamma Interventionpaper1
  19. The Mitochondrion as Nexuspaper1
  20. The Restorative Intervalpaper1
  21. The Senescent Frontpaper1
LRP1 Reelin, synapse & ECM–PNN 52 13 docs
Matched on LRP1
Often named withAPOEAPPMMP9PARP1ACAN (aggrecan)BCAN (brevican)
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper20
  2. The Vascular Dimensionpaper9
  3. The Locus Coeruleus Bridgepaper5
  4. The Temporal Architecture of Collapsepaper4
  5. The Vascular Phasingpaper3
  6. Endosomal Traffickingconcept2
  7. The Tide-gatepaper2
  8. The Unified Architecture of Collapsepaper2
  9. Cholesterol Homeostasisconcept1
  10. How the Brain's Clearance System Becomes the Disease's Highwaypaper1
  11. The Cellular Architecture of Collapsepaper1
  12. The Glymphatic Collapsepaper1
  13. The Senescent Frontpaper1
SORL1 GWAS / LOAD risk 52 13 docs
Matched on SORL1 SORLA
Often named withAPOEAPPTREM2V-ATPase (ATP6V)BIN1PSEN1
  1. The Complement-pruning Substratepaper23
  2. The Genetic Architecture of Neurodegenerationpaper9
  3. Endosomal Traffickingconcept4
  4. Convergent Synaptic Collapse (CSC) — Grading Referencepaper2
  5. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper2
  6. Endosomal Nexusnode2
  7. SORL1 Lysosomal Functionconcept2
  8. SorLA Lipid ER Regulationconcept2
  9. The Mitochondrion as Nexuspaper2
  10. Autophagic Collapseconcept1
  11. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  12. The Clearance Collapsepaper1
  13. The Temporal Architecture of Collapsepaper1
CLDN5 Vascular / BBB 51 4 docs
Matched on CLDN5 claudin-?5
Often named withAPOELRP1AGER (RAGE)AQP4BACE2IL6
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper37
  2. The Vascular Dimensionpaper7
  3. The Vascular Phasingpaper5
  4. The Tide-gatepaper2
KMO Neuromodulator / circadian / kynurenine 51 5 docs
Matched on KMO
Often named withAPOEIDO1TREM2IL6MTORTNF
  1. The Tryptophan Partitionpaper37
  2. The Depression Continuumpaper8
  3. The Biomarker Cascadepaper2
  4. The Genetic Architecture of Neurodegenerationpaper2
  5. The Viral Trajectorypaper2
FNDC5 (irisin) Trophic / exercise / resilience 50 2 docs
Matched on FNDC5 irisin
Often named withAPOEBDNFACAN (aggrecan)APPBCAN (brevican)CTSB
  1. The Muscle's Errandpaper48
  2. The Adult-born Neuronpaper2
GSK3B Amyloid & Tau core 49 20 docs
Matched on GSK3B GSK-?3β GSK-?3beta GSK-?3
Often named withAPOEAPPPSEN1DAB1LRP8 (ApoER2)ACAN (aggrecan)
  1. The Coerulean Pincerpaper9
  2. The Trojan Neuroblastpaper8
  3. The Matrix of Collapsepaper5
  4. Convergent Synaptic Collapse (CSC) — Grading Referencepaper3
  5. The Wax and the Weldpaper3
  6. Cytoskeletal Collapse Nodenode2
  7. Cytoskeletal Perturbationstage2
  8. The Architect's Reprievepaper2
  9. The Compressed Architecturepaper2
  10. The Viral Trajectorypaper2
  11. Wnt-GSK3-beta pathway integrating amyloid and tau pathologyconcept2
  12. Lipid Metabolismconcept1
  13. Perineuronal Netsconcept1
  14. Reelin-ApoE receptor axis disruptionconcept1
  15. The Architect's Handshakepaper1
  16. The Architect's Scaffoldpaper1
  17. The Architecture of Resistancepaper1
  18. The Energy-gated Tauopathypaper1
  19. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper1
  20. The Mitochondrion as Nexuspaper1
TARDBP (TDP-43) Neurodegeneration overlap 49 10 docs
Matched on TARDBP TDP-?43
Often named withAPOEAPPTREM2V-ATPase (ATP6V)CD38MMP9
  1. The Mitochondrion as Nexuspaper19
  2. The Genetic Architecture of Neurodegenerationpaper17
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  4. Phase Measurabilityconcept2
  5. The Trojan Neuroblastpaper2
  6. The Wax and the Weldpaper2
  7. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
  8. Fischer's Sideliningpaper1
  9. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper1
  10. The Tryptophan Partitionpaper1
FTH1/FTL (ferritin) Oxidative stress & ferroptosis 48 10 docs
Matched on ferritin FTH1 FTL
Often named withAPOEC1QAC3NLRP3TREM2ACAN (aggrecan)
  1. Iron Chelation and GPX4 Stabilizationpaper19
  2. Ferroptosis and the Phase II Oligodendrocyte Crisispaper14
  3. The Proteolytic Turnpaper3
  4. The Temporal Architecture of Collapsepaper3
  5. Cellular Senescenceconcept2
  6. The Cellular Architecture of Collapsepaper2
  7. The Senescent Frontpaper2
  8. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper1
  9. The Corruption of the Gardenerpaper1
  10. The Genetic Architecture of Neurodegenerationpaper1
PRKN Bioenergetic / mito / NAD 47 10 docs
Matched on PRKN parkin PARK2
Often named withAPOEPINK1APPC1QAC3PARP1
  1. The Mitochondrion as Nexuspaper17
  2. The Genetic Architecture of Neurodegenerationpaper14
  3. The Narrow Gatepaper4
  4. The Clearance Collapsepaper3
  5. The Temporal Architecture of Collapsepaper3
  6. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  7. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  8. The Cellular Architecture of Collapsepaper1
  9. The Senescent Frontpaper1
  10. The Unified Architecture of Collapsepaper1
SNCA Neurodegeneration overlap 47 8 docs
Matched on SNCA α-synuclein alpha-synuclein α-syn
Often named withAPOEAPPCD38SIRT3TARDBP (TDP-43)TREM2
  1. The Mitochondrion as Nexuspaper23
  2. The Genetic Architecture of Neurodegenerationpaper14
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  4. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper2
  5. The Microbial Prologuepaper2
  6. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper1
  7. PARP Inhibitors and the Locus Coeruleuspaper1
  8. The Narrow Gatepaper1
TIMP3 Reelin, synapse & ECM–PNN 47 6 docs
Matched on TIMP-?3
Often named withACAN (aggrecan)APPBCAN (brevican)MMP9APOEPSEN1
  1. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper24
  2. The Genetic Architecture of Neurodegenerationpaper13
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper7
  4. The Adult-born Neuronpaper1
  5. The Gamma Interventionpaper1
  6. The Locus Coeruleus Bridgepaper1
VLDLR Reelin, synapse & ECM–PNN 46 11 docs
Matched on VLDLR
Often named withAPOEDAB1LRP8 (ApoER2)RELNPSEN1APP
  1. The Coerulean Shearspaper16
  2. The Architect's Reprievepaper8
  3. The Coerulean Pincerpaper8
  4. Reelin-ApoE receptor axis disruptionconcept3
  5. The Genetic Architecture of Neurodegenerationpaper3
  6. APOE4 Hubnode2
  7. The Architect's Scaffoldpaper2
  8. Perineuronal Netsconcept1
  9. The Architect's Handshakepaper1
  10. The Architecture of Resistancepaper1
  11. The Unified Architecture of Collapsepaper1
TNF Microglia & innate immunity 44 24 docs
Matched on TNF
Often named withAPOETREM2IL6MMP9APPNLRP3
  1. The Spectrum of Collapsepaper6
  2. The Vagal Interfacepaper5
  3. The Viral Trajectorypaper3
  4. Anti-TNF-alpha therapeutic strategyconcept2
  5. Cellular Senescenceconcept2
  6. Ferroptosis and the Phase II Oligodendrocyte Crisispaper2
  7. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper2
  8. Neuroinflammationconcept2
  9. NAD⁺ Restoration and CD38 Inhibitionpaper2
  10. The Depression Continuumpaper2
  11. The Vascular Dimensionpaper2
  12. TNF-alpha as central AD mediatorconcept2
  13. Autophagic Collapseconcept1
  14. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
  15. Innate Immunityconcept1
  16. Lysosomal Acidificationconcept1
  17. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  18. The Biomarker Cascadepaper1
  19. The Complement-pruning Substratepaper1
  20. The DAM Trajectory and the Matrix-degrading Armpaper1
  21. The Mitochondrion as Nexuspaper1
  22. The Net and the Speckpaper1
  23. The Tryptophan Partitionpaper1
  24. The Vascular Phasingpaper1
ATP synthase (ATP5x) Bioenergetic / mito / NAD 43 5 docs
Matched on ATP5A1 ATP synthase OSCP ATP5PO
Often named withAPPPSEN1CD38MTORPRKAA (AMPK)APOE
  1. NAD⁺ Restoration and CD38 Inhibitionpaper21
  2. Iron Chelation and GPX4 Stabilizationpaper13
  3. AG18051 and the Aβ–ABAD Complexpaper4
  4. The Clearance Collapsepaper3
  5. The Mitochondrion as Nexuspaper2
CR3 Microglia & innate immunity 41 14 docs
Matched on CR3 CD11b ITGAM
Often named withAPOEC1QAC3TREM2APPMMP9
  1. The Complement-pruning Substratepaper11
  2. The Proteolytic Turnpaper8
  3. The Genetic Architecture of Neurodegenerationpaper6
  4. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper2
  5. The Cellular Architecture of Collapsepaper2
  6. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper2
  7. The Temporal Architecture of Collapsepaper2
  8. The Viral Trajectorypaper2
  9. Convergent Synaptic Collapse (CSC) — Grading Referencepaper1
  10. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  11. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  12. Neuroimmune Interfacenode1
  13. The Compressed Architecturepaper1
  14. The Trojan Neuroblastpaper1
BIN1 GWAS / LOAD risk 38 10 docs
Matched on BIN1
Often named withAPOEAPPSORL1PARP1PSEN1TREM2
  1. The Genetic Architecture of Neurodegenerationpaper12
  2. The Clearance Collapsepaper11
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  4. The Complement-pruning Substratepaper3
  5. BIN1 Autophagic Regulationconcept2
  6. The Fading Scorepaper2
  7. The Mitochondrion as Nexuspaper2
  8. Autophagyconcept1
  9. Endosomal Traffickingconcept1
  10. The Temporal Architecture of Collapsepaper1
HTRA1 Vascular / BBB 38 1 doc
Matched on HTRA1
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper38
C4 (complement) Microglia & innate immunity 37 14 docs
Matched on C4d C4b
Often named withAPOEC1QAC3ACAN (aggrecan)BCAN (brevican)MMP9
  1. The Matrix of Collapsepaper10
  2. The Cellular Architecture of Collapsepaper5
  3. The Proteolytic Turnpaper4
  4. The Temporal Architecture of Collapsepaper4
  5. Convergent Synaptic Collapse (CSC) — Grading Referencepaper2
  6. Neuroimmune Interfacenode2
  7. The Genetic Architecture of Neurodegenerationpaper2
  8. The Unified Architecture of Collapsepaper2
  9. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  10. Neuroinflammationconcept1
  11. Perineuronal Netsconcept1
  12. Shatz & Brottpaper1
  13. The Compressed Architecturepaper1
  14. The Senescent Frontpaper1
CD33 GWAS / LOAD risk 37 5 docs
Matched on CD33
Often named withMS4ATREM2APOEAPPPLCG2PSEN1
  1. The Architecture of Resistancepaper18
  2. The Genetic Architecture of Neurodegenerationpaper12
  3. The Sensor and the Speckpaper4
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  5. The DAM Trajectory and the Matrix-degrading Armpaper1
NFE2L2 (NRF2) Oxidative stress & ferroptosis 37 8 docs
Matched on NFE2L2 NRF2
Often named withAPPGPX4APOEMTORPSEN1CD38
  1. Ferroptosis and the Phase II Oligodendrocyte Crisispaper20
  2. The Genetic Architecture of Neurodegenerationpaper6
  3. The Mitochondrion as Nexuspaper3
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  5. NAD⁺ Restoration and CD38 Inhibitionpaper2
  6. Oxidative Stressconcept2
  7. Iron Chelation and GPX4 Stabilizationpaper1
  8. The Ketamine Paradoxpaper1
NOTCH3 Vascular / BBB 37 1 doc
Matched on NOTCH3
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper37
PP2A Amyloid & Tau core 36 5 docs
Matched on PP2A PPP2CA
Often named withAPOEAPPPSEN1BACE1CASP1CDK5
  1. The Silenced Eraserpaper30
  2. The Janus Lipidpaper2
  3. The Sensor and the Speckpaper2
  4. Lipid Metabolismconcept1
  5. The Energy-gated Tauopathypaper1
BACE2 Amyloid & Tau core 35 4 docs
Matched on BACE2
Often named withAGER (RAGE)APOEMMP9PARP1APPAQP4
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper23
  2. The Vascular Dimensionpaper8
  3. The Compressed Architecturepaper3
  4. The Vascular Phasingpaper1
CTSB Autophagy / lysosome / clearance 35 5 docs
Matched on CTSB cathepsin B
Often named withNLRP3ACAN (aggrecan)APPCASP1GSDMDPYCARD
  1. The Muscle's Errandpaper15
  2. The Sensor and the Speckpaper10
  3. The Net and the Speckpaper6
  4. One Sensor, Two Collapsespaper3
  5. The Cellular Architecture of Collapsepaper1
HDAC2 Epigenetic & senescence 35 2 docs
Matched on HDAC2
Often named withAPOESIRT1SIRT6ABI3ACAN (aggrecan)ADAM10
  1. The Architecture of Resistancepaper18
  2. The Fading Scorepaper17
PLCG2 GWAS / LOAD risk 35 4 docs
Matched on PLCG2
Often named withAPPCD33MS4APSEN1TREM2ABCA7
  1. The Architecture of Resistancepaper17
  2. The Genetic Architecture of Neurodegenerationpaper16
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  4. The Sensor and the Speckpaper1
NAMPT Bioenergetic / mito / NAD 34 5 docs
Matched on NAMPT
Often named withCD38PARP1APOEMTORSIRT3APP
  1. NAD⁺ Restoration and CD38 Inhibitionpaper16
  2. The Genetic Architecture of Neurodegenerationpaper8
  3. The Tryptophan Partitionpaper6
  4. PARP Inhibitors and the Locus Coeruleuspaper3
  5. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
TNR (tenascin-R) Reelin, synapse & ECM–PNN 34 16 docs
Matched on tenascin-?R TNR
Often named withACAN (aggrecan)APOEAPPBCAN (brevican)MMP9NCAN (neurocan)
  1. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper5
  2. Perineuronal Netsconcept4
  3. The Net and the Speckpaper4
  4. The Genetic Architecture of Neurodegenerationpaper3
  5. The Matrix of Collapsepaper3
  6. The Temporal Architecture of Collapsepaper3
  7. The Mitochondrion as Nexuspaper2
  8. The Perineuronal Turnpaper2
  9. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  10. One Sensor, Two Collapsespaper1
  11. The Architect's Scaffoldpaper1
  12. The Cellular Architecture of Collapsepaper1
  13. The Coerulean Shearspaper1
  14. The Gamma Interventionpaper1
  15. The Unified Architecture of Collapsepaper1
  16. The Viral Trajectorypaper1
SIRT1 Bioenergetic / mito / NAD 33 10 docs
Matched on SIRT1
Often named withAPOEAPPPARP1PSEN1SIRT3CD38
  1. NAD⁺ Restoration and CD38 Inhibitionpaper8
  2. The Architecture of Resistancepaper6
  3. PARP Inhibitors and the Locus Coeruleuspaper5
  4. The Genetic Architecture of Neurodegenerationpaper5
  5. SIRT1 neuroprotectionconcept2
  6. The Ketamine Paradoxpaper2
  7. The Mitochondrion as Nexuspaper2
  8. Autophagyconcept1
  9. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
  10. The Fading Scorepaper1
P2RY12 Microglia & innate immunity 32 18 docs
Matched on P2RY12 P2Y12
Often named withAPOEAPPTMEM119SALL1CX3CR1PSEN1
  1. The Silenced Eraserpaper9
  2. The Genetic Architecture of Neurodegenerationpaper4
  3. The Cellular Architecture of Collapsepaper2
  4. The Compressed Architecturepaper2
  5. The Corruption of the Gardenerpaper2
  6. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  7. Iron Chelation and GPX4 Stabilizationpaper1
  8. NAD⁺ Restoration and CD38 Inhibitionpaper1
  9. The DAM Trajectory and the Matrix-degrading Armpaper1
  10. The Depression Continuumpaper1
  11. The Fading Scorepaper1
  12. The Gamma Interventionpaper1
  13. The Mitochondrion as Nexuspaper1
  14. The Spectrum of Collapsepaper1
  15. The Temporal Architecture of Collapsepaper1
  16. The Trojan Neuroblastpaper1
  17. The Unified Architecture of Collapsepaper1
  18. The Vascular Phasingpaper1
SARM1 Bioenergetic / mito / NAD 30 7 docs
Matched on SARM1
Often named withPARP1APPGPX4PSEN1ADAMTS4APOE
  1. The Genetic Architecture of Neurodegenerationpaper16
  2. The Spectrum of Collapsepaper6
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  4. PARP Inhibitors and the Locus Coeruleuspaper2
  5. The Ketamine Paradoxpaper2
  6. Terminal Collapsepaper1
  7. The Temporal Architecture of Collapsepaper1
GSDMD Microglia & innate immunity 29 6 docs
Matched on GSDMD gasdermin
Often named withNLRP3APPCASP1PSEN1PYCARDTLR4
  1. The Sensor and the Speckpaper21
  2. One Sensor, Two Collapsespaper3
  3. The Net and the Speckpaper2
  4. The Depression Continuumpaper1
  5. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper1
  6. The Ketamine Paradoxpaper1
NLRP1 Microglia & innate immunity 29 2 docs
Matched on NLRP1
Often named withAPPCASP1CTSBGSDMDNLRP2NLRP3
  1. The Sensor and the Speckpaper27
  2. One Sensor, Two Collapsespaper2
TFEB Autophagy / lysosome / clearance 29 8 docs
Matched on TFEB
Often named withAPOEAPPPSEN1V-ATPase (ATP6V)BIN1MTOR
  1. The Clearance Collapsepaper11
  2. The Genetic Architecture of Neurodegenerationpaper7
  3. The Ketamine Paradoxpaper3
  4. The Mitochondrion as Nexuspaper3
  5. Gut Brain Axisconcept2
  6. Autophagyconcept1
  7. Lysosomal Acidificationconcept1
  8. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
MS4A GWAS / LOAD risk 28 5 docs
Matched on MS4A4A MS4A6A MS4A
Often named withCD33TREM2APOEAPPPLCG2PSEN1
  1. The Genetic Architecture of Neurodegenerationpaper15
  2. The Architecture of Resistancepaper9
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  4. The DAM Trajectory and the Matrix-degrading Armpaper1
  5. The Sensor and the Speckpaper1
CX3CR1 Microglia & innate immunity 27 13 docs
Matched on CX3CR1
Often named withAPOEP2RY12APPMMP9TREM2ACAN (aggrecan)
  1. The Silenced Eraserpaper7
  2. The Genetic Architecture of Neurodegenerationpaper4
  3. The Cellular Architecture of Collapsepaper2
  4. The Corruption of the Gardenerpaper2
  5. The Gamma Interventionpaper2
  6. The Locus Coeruleus Bridgepaper2
  7. The Temporal Architecture of Collapsepaper2
  8. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  9. The Compressed Architecturepaper1
  10. The DAM Trajectory and the Matrix-degrading Armpaper1
  11. The Mitochondrion as Nexuspaper1
  12. The Unified Architecture of Collapsepaper1
  13. The Vascular Phasingpaper1
ADAMTS4 Reelin, synapse & ECM–PNN 26 11 docs
Matched on ADAMTS-?4
Often named withMMP9ACAN (aggrecan)APOEBCAN (brevican)MMP2ADAMTS5
  1. The Net and the Speckpaper8
  2. The Genetic Architecture of Neurodegenerationpaper5
  3. The Proteolytic Turnpaper3
  4. One Sensor, Two Collapsespaper2
  5. The Compressed Architecturepaper2
  6. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  7. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper1
  8. Perineuronal Netsconcept1
  9. The DAM Trajectory and the Matrix-degrading Armpaper1
  10. The Spectrum of Collapsepaper1
  11. The Temporal Architecture of Collapsepaper1
ADAMTS5 Reelin, synapse & ECM–PNN 26 7 docs
Matched on ADAMTS-?5
Often named withADAMTS4ACAN (aggrecan)MMP9APOEBCAN (brevican)MMP2
  1. The Net and the Speckpaper11
  2. The Compressed Architecturepaper5
  3. One Sensor, Two Collapsespaper4
  4. The Genetic Architecture of Neurodegenerationpaper3
  5. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  6. The DAM Trajectory and the Matrix-degrading Armpaper1
  7. The Proteolytic Turnpaper1
AGER (RAGE) Vascular / BBB 25 5 docs
Matched on AGER RAGE
Often named withAPOEMMP9APPBACE2IL6P2RY12
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper17
  2. The Vascular Dimensionpaper4
  3. The Vascular Phasingpaper2
  4. The Compressed Architecturepaper1
  5. The Depression Continuumpaper1
DYRK1A Amyloid & Tau core 25 1 doc
Matched on DYRK1A
Often named withACAN (aggrecan)ADAMTS1ADAMTS4ADAMTS5AGER (RAGE)APOE
  1. The Compressed Architecturepaper25
SIRT3 Bioenergetic / mito / NAD 25 8 docs
Matched on SIRT3
Often named withAPOEAPPCD38PARP1PSEN1SIRT1
  1. NAD⁺ Restoration and CD38 Inhibitionpaper8
  2. PARP Inhibitors and the Locus Coeruleuspaper8
  3. The Genetic Architecture of Neurodegenerationpaper3
  4. The Architecture of Resistancepaper2
  5. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
  6. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  7. The Clearance Collapsepaper1
  8. The Mitochondrion as Nexuspaper1
MAPT Amyloid & Tau core 24 3 docs
Matched on MAPT
Often named withAPOEAPPCR3P2RY12SALL1TARDBP (TDP-43)
  1. The Genetic Architecture of Neurodegenerationpaper18
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper4
  3. The Trojan Neuroblastpaper2
MFSD2A Vascular / BBB 24 3 docs
Matched on MFSD2A
Often named withAGER (RAGE)APOEAQP4BACE2CLDN5IL6
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper17
  2. The Vascular Dimensionpaper4
  3. The Vascular Phasingpaper3
QPRT Neuromodulator / circadian / kynurenine 24 2 docs
Matched on QPRT
Often named withAPOECD38GRIN2BIDO1KMOMTOR
  1. The Tryptophan Partitionpaper22
  2. The Genetic Architecture of Neurodegenerationpaper2
SLC2A1 (GLUT1) Vascular / BBB 24 3 docs
Matched on GLUT1 SLC2A1
Often named withAGER (RAGE)APOEAQP4BACE2CLDN5IL6
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper15
  2. The Vascular Dimensionpaper6
  3. The Vascular Phasingpaper3
SOD1 Oxidative stress & ferroptosis 24 5 docs
Matched on SOD1
Often named withAPOEAPPACAN (aggrecan)C1QAC3CD38
  1. The Genetic Architecture of Neurodegenerationpaper10
  2. The Compressed Architecturepaper8
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  4. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper2
  5. The Mitochondrion as Nexuspaper1
GRN (progranulin) Autophagy / lysosome / clearance 23 3 docs
Matched on progranulin GRN
Often named withAPOEAPPCX3CR1P2RY12PSEN1TREM2
  1. The Genetic Architecture of Neurodegenerationpaper17
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper4
  3. The Corruption of the Gardenerpaper2
C9ORF72 Neurodegeneration overlap 22 3 docs
Matched on C9ORF72
Often named withAPOEAPPCD38MMP2MMP9SIRT3
  1. The Genetic Architecture of Neurodegenerationpaper16
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper5
  3. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
CDKN1A (p21) Epigenetic & senescence 22 3 docs
Matched on CDKN1A p21
Often named withCD38MMP2NLRP3ACAN (aggrecan)APOEBCAN (brevican)
  1. The Senescent Frontpaper11
  2. Cellular Senescenceconcept7
  3. The Unified Architecture of Collapsepaper4
IL6 Microglia & innate immunity 19 12 docs
Matched on IL-?6
Often named withTNFAPOETREM2CD38MMP9MTOR
  1. Cellular Senescenceconcept4
  2. The Depression Continuumpaper3
  3. The Vascular Dimensionpaper2
  4. The Vascular Phasingpaper2
  5. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  6. NAD⁺ Restoration and CD38 Inhibitionpaper1
  7. The Biomarker Cascadepaper1
  8. The Complement-pruning Substratepaper1
  9. The DAM Trajectory and the Matrix-degrading Armpaper1
  10. The Mitochondrion as Nexuspaper1
  11. The Tryptophan Partitionpaper1
  12. The Viral Trajectorypaper1
LILRB2 GWAS / LOAD risk 19 8 docs
Matched on LILRB2 PirB
Often named withC4 (complement)APOEC1QATREM2ACAN (aggrecan)BCAN (brevican)
  1. The Matrix of Collapsepaper8
  2. Convergent Synaptic Collapse (CSC) — Grading Referencepaper2
  3. Neuroimmune Interfacenode2
  4. The Cellular Architecture of Collapsepaper2
  5. The Temporal Architecture of Collapsepaper2
  6. Perineuronal Netsconcept1
  7. Shatz & Brottpaper1
  8. The Unified Architecture of Collapsepaper1
TDO2 Neuromodulator / circadian / kynurenine 19 4 docs
Matched on TDO2 TDO
Often named withIDO1MTORAPOEAPPCD38IL6
  1. The Tryptophan Partitionpaper16
  2. NAD⁺ Restoration and CD38 Inhibitionpaper1
  3. The Depression Continuumpaper1
  4. The Genetic Architecture of Neurodegenerationpaper1
TPH2 Neuromodulator / circadian / kynurenine 19 3 docs
Matched on TPH2
Often named withAPOEIDO1KMOMTORTDO2TREM2
  1. The Tryptophan Partitionpaper13
  2. The Depression Continuumpaper5
  3. The Genetic Architecture of Neurodegenerationpaper1
VCAN (versican) Reelin, synapse & ECM–PNN 19 13 docs
Matched on VCAN versican
Often named withACAN (aggrecan)BCAN (brevican)NCAN (neurocan)MMP9TNR (tenascin-R)APOE
  1. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper3
  2. The Genetic Architecture of Neurodegenerationpaper3
  3. The Net and the Speckpaper3
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  5. Perineuronal Netsconcept1
  6. The Cellular Architecture of Collapsepaper1
  7. The Coerulean Pincerpaper1
  8. The Coerulean Shearspaper1
  9. The Gamma Interventionpaper1
  10. The Matrix of Collapsepaper1
  11. The Perineuronal Turnpaper1
  12. The Proteolytic Turnpaper1
  13. The Unified Architecture of Collapsepaper1
GBA Neurodegeneration overlap 18 3 docs
Matched on GBA1 GBA
Often named withACAN (aggrecan)APOEAPPBACE1BIN1C1QA
  1. The Genetic Architecture of Neurodegenerationpaper14
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  3. The Mitochondrion as Nexuspaper1
KCNC (Kv3) Neuromodulator / circadian / kynurenine 18 4 docs
Matched on Kv3 KCNC1 KCNC3
Often named withACAN (aggrecan)APPBCAN (brevican)C1QAC3HAPLN1
  1. The Genetic Architecture of Neurodegenerationpaper10
  2. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper5
  3. The Gamma Interventionpaper2
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
TMEM119 Microglia & innate immunity 18 15 docs
Matched on TMEM119
Often named withP2RY12APOEAPPSALL1MMP9CX3CR1
  1. The Compressed Architecturepaper2
  2. The Genetic Architecture of Neurodegenerationpaper2
  3. The Silenced Eraserpaper2
  4. Iron Chelation and GPX4 Stabilizationpaper1
  5. NAD⁺ Restoration and CD38 Inhibitionpaper1
  6. The Cellular Architecture of Collapsepaper1
  7. The DAM Trajectory and the Matrix-degrading Armpaper1
  8. The Depression Continuumpaper1
  9. The Fading Scorepaper1
  10. The Gamma Interventionpaper1
  11. The Spectrum of Collapsepaper1
  12. The Temporal Architecture of Collapsepaper1
  13. The Trojan Neuroblastpaper1
  14. The Unified Architecture of Collapsepaper1
  15. The Vascular Phasingpaper1
CDKN2A (p16) Epigenetic & senescence 17 2 docs
Matched on CDKN2A p16INK4a p16
Often named withCD38CDKN1A (p21)FTH1/FTL (ferritin)LMNB1MMP2NLRP3
  1. The Senescent Frontpaper11
  2. Cellular Senescenceconcept6
COL4A1 Vascular / BBB 17 1 doc
Matched on COL4A1
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper17
KL (klotho) Trophic / exercise / resilience 17 1 doc
Matched on klotho
Often named withABI3ADAM10APOEAPPBACE1CD33
  1. The Architecture of Resistancepaper17
NCAN (neurocan) Reelin, synapse & ECM–PNN 17 13 docs
Matched on NCAN neurocan
Often named withACAN (aggrecan)BCAN (brevican)VCAN (versican)MMP9TNR (tenascin-R)APOE
  1. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper3
  2. The Genetic Architecture of Neurodegenerationpaper3
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  4. Perineuronal Netsconcept1
  5. The Cellular Architecture of Collapsepaper1
  6. The Coerulean Pincerpaper1
  7. The Coerulean Shearspaper1
  8. The Gamma Interventionpaper1
  9. The Matrix of Collapsepaper1
  10. The Net and the Speckpaper1
  11. The Perineuronal Turnpaper1
  12. The Proteolytic Turnpaper1
  13. The Unified Architecture of Collapsepaper1
PSEN2 Amyloid & Tau core 17 6 docs
Matched on PSEN2 PS2 presenilin[- ]?2
Often named withAPOEPSEN1APPBACE1ABI3CD33
  1. The Genetic Architecture of Neurodegenerationpaper6
  2. The Wax and the Weldpaper5
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  4. The Case for the Cascadepaper2
  5. The Architecture of Resistancepaper1
  6. The Pv+/gamma Axispaper1
ABCA7 GWAS / LOAD risk 16 3 docs
Matched on ABCA7
Often named withAPPCD33INPP5DMS4APLCG2PSEN1
  1. The Genetic Architecture of Neurodegenerationpaper13
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  3. The Sensor and the Speckpaper1
LRRK2 Neurodegeneration overlap 16 4 docs
Matched on LRRK2
Often named withAPOEPARP1APPBACE1MMP9ABCA1
  1. The Genetic Architecture of Neurodegenerationpaper11
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  3. The Energy-gated Tauopathypaper1
  4. The Vascular Dimensionpaper1
TOMM20 Bioenergetic / mito / NAD 16 6 docs
Matched on TOM20 TOMM20
Often named withAPOEAPPPINK1TOM40PRKNMTOR
  1. The Narrow Gatepaper8
  2. The Clearance Collapsepaper2
  3. The Mitochondrion as Nexuspaper2
  4. The Temporal Architecture of Collapsepaper2
  5. The Unified Architecture of Collapsepaper1
  6. TOMM40 Import Gateconcept1
PICALM GWAS / LOAD risk 15 5 docs
Matched on PICALM
Often named withAPOEAPPBIN1BACE1PSEN1SORL1
  1. The Genetic Architecture of Neurodegenerationpaper9
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  3. Autophagyconcept1
  4. Endosomal Traffickingconcept1
  5. The Mitochondrion as Nexuspaper1
SALL1 Microglia & innate immunity 15 13 docs
Matched on SALL1
Often named withP2RY12TMEM119APOEAPPMMP9ACAN (aggrecan)
  1. The Genetic Architecture of Neurodegenerationpaper3
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  3. Iron Chelation and GPX4 Stabilizationpaper1
  4. NAD⁺ Restoration and CD38 Inhibitionpaper1
  5. The Cellular Architecture of Collapsepaper1
  6. The DAM Trajectory and the Matrix-degrading Armpaper1
  7. The Depression Continuumpaper1
  8. The Fading Scorepaper1
  9. The Gamma Interventionpaper1
  10. The Temporal Architecture of Collapsepaper1
  11. The Trojan Neuroblastpaper1
  12. The Unified Architecture of Collapsepaper1
  13. The Vascular Phasingpaper1
SQSTM1 (p62) Autophagy / lysosome / clearance 15 7 docs
Matched on SQSTM1 p62
Often named withAPPGPX4PARP1PSEN1APOEC1QA
  1. The Genetic Architecture of Neurodegenerationpaper5
  2. The Clearance Collapsepaper3
  3. The Mitochondrion as Nexuspaper3
  4. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  5. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  6. The Ketamine Paradoxpaper1
  7. The Spectrum of Collapsepaper1
ARNTL (BMAL1) Neuromodulator / circadian / kynurenine 14 3 docs
Matched on BMAL1 ARNTL
Often named withAPOEBECN1BIN1C1QAC3CR1
  1. The Complement-pruning Substratepaper11
  2. The Pineal Interfacepaper2
  3. Viral Pathogenesisconcept1
NGF Trophic / exercise / resilience 14 3 docs
Matched on nerve growth factor NGF
Often named withADAMTS4APPBDNFC1QAC3MMP9
  1. The Spectrum of Collapsepaper7
  2. The Compressed Architecturepaper4
  3. The Withdrawn Subsidypaper3
OLIG2 Down-syndrome chr21 14 3 docs
Matched on OLIG2
Often named withACAN (aggrecan)ADAMTS4ADAMTS5APOEAPPBCAN (brevican)
  1. The Compressed Architecturepaper10
  2. The Genetic Architecture of Neurodegenerationpaper3
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
PDGFRB Vascular / BBB 14 2 docs
Matched on PDGFRB PDGFR-?β
Often named withAGER (RAGE)APOEAPPAQP4BACE1BACE2
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper13
  2. The Vascular Dimensionpaper1
PRKAA (AMPK) Bioenergetic / mito / NAD 14 6 docs
Matched on AMPK PRKAA1 PRKAA2
Often named withAPPMTORPSEN1APOEATP synthase (ATP5x)CD38
  1. The Clearance Collapsepaper4
  2. The Depression Continuumpaper4
  3. NAD⁺ Restoration and CD38 Inhibitionpaper2
  4. The Mitochondrion as Nexuspaper2
  5. Iron Chelation and GPX4 Stabilizationpaper1
  6. The Ketamine Paradoxpaper1
SDC (syndecan) Reelin, synapse & ECM–PNN 14 2 docs
Matched on SDC1 SDC2 SDC3 SDC4 syndecan
Often named withACAN (aggrecan)APOEAPPBCAN (brevican)DAB1LRP8 (ApoER2)
  1. The Coerulean Shearspaper9
  2. The Coerulean Pincerpaper5
TLR4 Microglia & innate immunity 14 9 docs
Matched on TLR4
Often named withNLRP3PYCARDTNFTREM2APOEAPP
  1. The Net and the Speckpaper4
  2. The Sensor and the Speckpaper3
  3. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  4. Neuroinflammationconcept1
  5. NAD⁺ Restoration and CD38 Inhibitionpaper1
  6. One Sensor, Two Collapsespaper1
  7. The Corruption of the Gardenerpaper1
  8. The Depression Continuumpaper1
  9. The Tryptophan Partitionpaper1
TREX1 Vascular / BBB 14 1 doc
Matched on TREX1
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper14
ABCA1 GWAS / LOAD risk 13 5 docs
Matched on ABCA1
Often named withAPOEAPPBACE1PSEN1V-ATPase (ATP6V)SORL1
  1. The Genetic Architecture of Neurodegenerationpaper5
  2. Cholesterol Homeostasisconcept4
  3. Lipid Metabolismconcept2
  4. Autophagic Collapseconcept1
  5. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
CGAS Microglia & innate immunity 13 4 docs
Matched on cGAS CGAS
Often named withAPOEPARP1STINGACAN (aggrecan)APPBIN1
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper5
  2. The Mitochondrion as Nexuspaper4
  3. The Fading Scorepaper3
  4. The Viral Trajectorypaper1
FOXC1 Vascular / BBB 13 1 doc
Matched on FOXC1
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper13
FUS Neurodegeneration overlap 13 3 docs
Matched on FUS
Often named withAPPMMP9PSEN1TARDBP (TDP-43)ABCA1ABCA7
  1. The Genetic Architecture of Neurodegenerationpaper10
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  3. Fischer's Sideliningpaper1
HAPLN1 Reelin, synapse & ECM–PNN 13 6 docs
Matched on HAPLN1
Often named withACAN (aggrecan)BCAN (brevican)MMP9NCAN (neurocan)TNR (tenascin-R)VCAN (versican)
  1. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper5
  2. The Genetic Architecture of Neurodegenerationpaper3
  3. Perineuronal Netsconcept2
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  5. The Cellular Architecture of Collapsepaper1
  6. The Gamma Interventionpaper1
MFN2 Bioenergetic / mito / NAD 13 4 docs
Matched on MFN2
Often named withAPOEAPPBACE1PSEN1TARDBP (TDP-43)ACAN (aggrecan)
  1. The Wax and the Weldpaper7
  2. The Genetic Architecture of Neurodegenerationpaper4
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  4. The Mitochondrion as Nexuspaper1
ARHGEF15 (Ephexin5) Reelin, synapse & ECM–PNN 12 5 docs
Matched on Ephexin-?5 ARHGEF15
Often named withAPOEDAB1GSK3BLIMK1LRP8 (ApoER2)C1QA
  1. The Matrix of Collapsepaper5
  2. Convergent Synaptic Collapse (CSC) — Grading Referencepaper3
  3. Cytoskeletal Collapse Nodenode2
  4. APOE4 Hubnode1
  5. Margolispaper1
CLU GWAS / LOAD risk 12 4 docs
Matched on clusterin CLU
Often named withAPOEACSL4AIFM2 (FSP1)ALOX15C1QAC3
  1. The Genetic Architecture of Neurodegenerationpaper8
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  3. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  4. The Tide-gatepaper1
CR1 GWAS / LOAD risk 12 3 docs
Matched on CR1
Often named withAPOEBIN1C1QAC3CR3MMP9
  1. The Genetic Architecture of Neurodegenerationpaper8
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  3. The Complement-pruning Substratepaper1
NLRP2 Microglia & innate immunity 12 2 docs
Matched on NLRP2
Often named withAPPCASP1CTSBGSDMDNLRP1NLRP3
  1. The Sensor and the Speckpaper11
  2. One Sensor, Two Collapsespaper1
S100B Reelin, synapse & ECM–PNN 12 1 doc
Matched on S100B S100β
Often named withACAN (aggrecan)ADAMTS1ADAMTS4ADAMTS5AGER (RAGE)APOE
  1. The Compressed Architecturepaper12
STING Microglia & innate immunity 12 5 docs
Matched on TMEM173 STING
Often named withAPOEPARP1ACAN (aggrecan)APPBIN1C1QA
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper5
  2. The Fading Scorepaper3
  3. The Mitochondrion as Nexuspaper2
  4. The Genetic Architecture of Neurodegenerationpaper1
  5. The Viral Trajectorypaper1
TYROBP GWAS / LOAD risk 12 7 docs
Matched on TYROBP DAP12
Often named withTREM2ACAN (aggrecan)APOEAPPC1QAC3
  1. The Genetic Architecture of Neurodegenerationpaper6
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  3. Metabolic-Homeostatic Axisnode1
  4. The Cellular Architecture of Collapsepaper1
  5. The Mitochondrion as Nexuspaper1
  6. The Temporal Architecture of Collapsepaper1
  7. The Unified Architecture of Collapsepaper1
ABI3 GWAS / LOAD risk 11 3 docs
Matched on ABI3
Often named withAPOEAPPBACE1CD33MS4APLCG2
  1. The Genetic Architecture of Neurodegenerationpaper8
  2. The Architecture of Resistancepaper2
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
FOXP3 Microglia & innate immunity 11 2 docs
Matched on FOXP3
Often named withAPOEAPPCLDN5CLULRP1PSEN1
  1. The Peacekeeper's Paradoxpaper10
  2. The Tide-gatepaper1
OPTN Neurodegeneration overlap 11 4 docs
Matched on OPTN optineurin
Often named withAPOEAPPBIN1CD38MAP1LC3B (LC3)MTOR
  1. The Genetic Architecture of Neurodegenerationpaper6
  2. The Clearance Collapsepaper2
  3. The Mitochondrion as Nexuspaper2
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
SPI1 GWAS / LOAD risk 11 4 docs
Matched on SPI1 PU\.1
Often named withAPPPSEN1TREM2ABCA7ACAN (aggrecan)ADAMTS4
  1. The Genetic Architecture of Neurodegenerationpaper8
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  3. The Sensor and the Speckpaper1
  4. The Temporal Architecture of Collapsepaper1
TIMM23 Bioenergetic / mito / NAD 11 3 docs
Matched on TIM23 TIMM23
Often named withAPOEAPPHSD17B10PINK1TOM40TOMM20
  1. The Narrow Gatepaper8
  2. The Mitochondrion as Nexuspaper2
  3. TOMM40 Import Gateconcept1
VPS35 Autophagy / lysosome / clearance 11 4 docs
Matched on VPS35
Often named withAPOEAPPPSEN1SORL1BIN1DAB1
  1. The Genetic Architecture of Neurodegenerationpaper8
  2. Endosomal Nexusnode1
  3. The Clearance Collapsepaper1
  4. The Temporal Architecture of Collapsepaper1
CSF1R Microglia & innate immunity 10 5 docs
Matched on CSF1R
Often named withAPOEMMP2MMP9TREM2ACAN (aggrecan)ADAMTS4
  1. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper5
  2. Perineuronal Netsconcept2
  3. Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
  4. The Proteolytic Turnpaper1
  5. The Trojan Neuroblastpaper1
NMNAT2 Bioenergetic / mito / NAD 10 4 docs
Matched on NMNAT2
Often named withADAMTS4APPC1QAC3GPX4MMP9
  1. The Genetic Architecture of Neurodegenerationpaper6
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  3. The Spectrum of Collapsepaper1
  4. The Temporal Architecture of Collapsepaper1
VDAC1 Bioenergetic / mito / NAD 10 3 docs
Matched on VDAC1 VDAC
Often named withAPOEAPPBACE1GSK3BHSD17B10MFN2
  1. The Wax and the Weldpaper7
  2. The Mitochondrion as Nexuspaper2
  3. The Narrow Gatepaper1
ACSL4 Oxidative stress & ferroptosis 9 3 docs
Matched on ACSL4
Often named withAIFM2 (FSP1)ALOX15APOEC1QAC3CLU
  1. Ferroptosis and the Phase II Oligodendrocyte Crisispaper6
  2. The Genetic Architecture of Neurodegenerationpaper2
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
ADAMTS1 Reelin, synapse & ECM–PNN 9 4 docs
Matched on ADAMTS-?1
Often named withACAN (aggrecan)ADAMTS4BCAN (brevican)MMP9APOEMMP2
  1. The Compressed Architecturepaper5
  2. The Net and the Speckpaper2
  3. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper1
  4. Perineuronal Netsconcept1
MAP1LC3B (LC3) Autophagy / lysosome / clearance 9 5 docs
Matched on MAP1LC3B LC3
Often named withAPPAPOEBIN1CD38MTOROPTN
  1. The Genetic Architecture of Neurodegenerationpaper4
  2. The Mitochondrion as Nexuspaper2
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  4. Plaque Origin What is Establishedconcept1
  5. The Clearance Collapsepaper1
PPARGC1A Bioenergetic / mito / NAD 9 1 doc
Matched on PPARGC1A PGC-?1α PGC-?1alpha PGC-?1a
Often named withACAN (aggrecan)APOEAPPATP synthase (ATP5x)BACE1BIN1
  1. The Mitochondrion as Nexuspaper9
ALOX15 Oxidative stress & ferroptosis 8 5 docs
Matched on ALOX15 15-LOX
Often named withAPOEGPX4AIFM2 (FSP1)NFE2L2 (NRF2)PSEN1ACSL4
  1. Ferroptosis and the Phase II Oligodendrocyte Crisispaper2
  2. Lipid Peroxidationconcept2
  3. The Genetic Architecture of Neurodegenerationpaper2
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  5. Iron Chelation and GPX4 Stabilizationpaper1
BECN1 Autophagy / lysosome / clearance 8 5 docs
Matched on BECN1 Beclin
Often named withAPOEAPPBIN1PSEN1TFEBV-ATPase (ATP6V)
  1. The Genetic Architecture of Neurodegenerationpaper3
  2. Viral Pathogenesisconcept2
  3. Autophagyconcept1
  4. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  5. The Clearance Collapsepaper1
CD2AP GWAS / LOAD risk 8 3 docs
Matched on CD2AP
Often named withAPOEAPPBACE1BIN1PICALMSORL1
  1. The Genetic Architecture of Neurodegenerationpaper6
  2. Endosomal Traffickingconcept1
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
DLG4 (PSD-95) Reelin, synapse & ECM–PNN 8 6 docs
Matched on DLG4 PSD-?95
Often named withAPOEAPPC1QAC3PSEN1DAB1
  1. The Genetic Architecture of Neurodegenerationpaper3
  2. Convergent Synaptic Collapse (CSC) — Grading Referencepaper1
  3. Cytoskeletal Collapse Nodenode1
  4. Synaptic Pathologyconcept1
  5. The Architect's Handshakepaper1
  6. The Gamma Interventionpaper1
DNM1L Bioenergetic / mito / NAD 8 3 docs
Matched on DRP1 DNM1L
Often named withACAN (aggrecan)APOEAPPBACE1BIN1C1QA
  1. The Mitochondrion as Nexuspaper4
  2. The Genetic Architecture of Neurodegenerationpaper3
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
HAS1/2/3 Reelin, synapse & ECM–PNN 8 4 docs
Matched on HAS1 HAS2 HAS3 hyaluronan synthase
Often named withACAN (aggrecan)ADAMTS4APOEBCAN (brevican)HAPLN1MMP2
  1. The Genetic Architecture of Neurodegenerationpaper5
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  3. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper1
  4. Perineuronal Netsconcept1
INPP5D GWAS / LOAD risk 8 3 docs
Matched on INPP5D SHIP1
Often named withABCA7APPCD33MS4APLCG2PSEN1
  1. The Genetic Architecture of Neurodegenerationpaper6
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  3. The Sensor and the Speckpaper1
MEF2C GWAS / LOAD risk 8 2 docs
Matched on MEF2C
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. The Genetic Architecture of Neurodegenerationpaper7
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
DBH Neuromodulator / circadian / kynurenine 7 3 docs
Matched on DBH dopamine β-hydroxylase
Often named withACAN (aggrecan)APOEAPPBCAN (brevican)CX3CR1GPX4
  1. The Genetic Architecture of Neurodegenerationpaper5
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
  3. The Locus Coeruleus Bridgepaper1
ITGAX Microglia & innate immunity 7 6 docs
Matched on ITGAX CD11c
Often named withAPOEP2RY12SALL1TMEM119TREM2ACAN (aggrecan)
  1. The DAM Trajectory and the Matrix-degrading Armpaper2
  2. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  3. The Cellular Architecture of Collapsepaper1
  4. The Fading Scorepaper1
  5. The Genetic Architecture of Neurodegenerationpaper1
  6. The Temporal Architecture of Collapsepaper1
LIMK1 Reelin, synapse & ECM–PNN 7 3 docs
Matched on LIMK1
Often named withARHGEF15 (Ephexin5)GSK3BAPOEC1QAC4 (complement)DAB1
  1. The Matrix of Collapsepaper3
  2. Convergent Synaptic Collapse (CSC) — Grading Referencepaper2
  3. Cytoskeletal Collapse Nodenode2
NQO2 Oxidative stress & ferroptosis 7 3 docs
Matched on NQO2
Often named withAPPATP synthase (ATP5x)PSEN1CD38GPX4MTOR
  1. Iron Chelation and GPX4 Stabilizationpaper3
  2. NAD⁺ Restoration and CD38 Inhibitionpaper3
  3. AG18051 and the Aβ–ABAD Complexpaper1
OPA1 Bioenergetic / mito / NAD 7 3 docs
Matched on OPA1
Often named withACAN (aggrecan)APOEAPPBACE1BIN1C1QA
  1. The Genetic Architecture of Neurodegenerationpaper4
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper2
  3. The Mitochondrion as Nexuspaper1
SIRT6 Bioenergetic / mito / NAD 7 4 docs
Matched on SIRT6
Often named withSIRT1APOEAPPP2RY12PARP1PSEN1
  1. The Architecture of Resistancepaper3
  2. The Fading Scorepaper2
  3. NAD⁺ Restoration and CD38 Inhibitionpaper1
  4. The Genetic Architecture of Neurodegenerationpaper1
SOD2 Oxidative stress & ferroptosis 7 3 docs
Matched on SOD2
Often named withAPPCD38MTORNFE2L2 (NRF2)P2RY12PARP1
  1. The Genetic Architecture of Neurodegenerationpaper4
  2. The Mitochondrion as Nexuspaper2
  3. NAD⁺ Restoration and CD38 Inhibitionpaper1
TMEM106B Autophagy / lysosome / clearance 7 1 doc
Matched on TMEM106B
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. The Genetic Architecture of Neurodegenerationpaper7
TP53 (p53) Epigenetic & senescence 7 5 docs
Matched on TP53 p53
Often named withCD38PARP1APOEFTH1/FTL (ferritin)MMP2MTOR
  1. The Senescent Frontpaper3
  2. Cellular Senescenceconcept1
  3. NAD⁺ Restoration and CD38 Inhibitionpaper1
  4. PARP Inhibitors and the Locus Coeruleuspaper1
  5. The Genetic Architecture of Neurodegenerationpaper1
ADAM10 Amyloid & Tau core 6 5 docs
Matched on ADAM10
Often named withAPOEAPPTREM2ACAN (aggrecan)BACE1HSD17B10
  1. The Architecture of Resistancepaper2
  2. MMP-9 Inhibitors and the Phase III Therapeutic Windowpaper1
  3. The Biomarker Cascadepaper1
  4. The Narrow Gatepaper1
  5. TOMM40 Import Gateconcept1
C5AR1 Microglia & innate immunity 6 1 doc
Matched on C5aR C5AR1
Often named withAPOEAPPC1QAC3CR3GSDMD
  1. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper6
GRIN2B Reelin, synapse & ECM–PNN 6 3 docs
Matched on GRIN2B GluN2B NR2B
Often named withAPOETREM2ABI3APPBACE1CD33
  1. The Tryptophan Partitionpaper3
  2. The Architecture of Resistancepaper2
  3. The Genetic Architecture of Neurodegenerationpaper1
IL1B Microglia & innate immunity 6 2 docs
Matched on IL-?1β IL-?1beta IL1B IL-?1b
Often named withAPOEC1QAC3NLRP3TNFTREM2
  1. The Mitochondrion as Nexuspaper4
  2. Neuroinflammationconcept2
TFAM Bioenergetic / mito / NAD 6 2 docs
Matched on TFAM
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. The Genetic Architecture of Neurodegenerationpaper5
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
TLR2 Microglia & innate immunity 6 3 docs
Matched on TLR2
Often named withNLRP3PYCARDTLR4ACAN (aggrecan)ADAMTS4ADAMTS5
  1. The Net and the Speckpaper4
  2. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  3. One Sensor, Two Collapsespaper1
EPHA1 GWAS / LOAD risk 5 2 docs
Matched on EPHA1
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. The Genetic Architecture of Neurodegenerationpaper4
  2. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
GCLC Oxidative stress & ferroptosis 5 3 docs
Matched on GCLC
Often named withACSL4AIFM2 (FSP1)ALOX15APOEC1QAC3
  1. Ferroptosis and the Phase II Oligodendrocyte Crisispaper2
  2. The Genetic Architecture of Neurodegenerationpaper2
  3. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper1
ICAM1 Vascular / BBB 5 2 docs
Matched on ICAM-?1
Often named withAGER (RAGE)APOEAQP4BACE2CLDN5CX3CR1
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  2. The Vascular Phasingpaper2
IFNAR1/2 Down-syndrome chr21 5 2 docs
Matched on IFNAR1 IFNAR2 IFNAR
Often named withAPOEAPPC1QAC3CR3GSK3B
  1. The Compressed Architecturepaper4
  2. The Viral Trajectorypaper1
IL18 Microglia & innate immunity 5 4 docs
Matched on IL-?18
Often named withAPPNLRP3PSEN1APOECASP1GSDMD
  1. The Ketamine Paradoxpaper2
  2. The Depression Continuumpaper1
  3. The INFLAMMASOME-COMPLEMENT-TREM2 Nexuspaper1
  4. The Mitochondrion as Nexuspaper1
LMNB1 Epigenetic & senescence 5 4 docs
Matched on LMNB1 lamin B1
Often named withACAN (aggrecan)APOEBCAN (brevican)CD38CDKN1A (p21)CDKN2A (p16)
  1. The Fading Scorepaper2
  2. Cellular Senescenceconcept1
  3. Tau Propagationconcept1
  4. The Senescent Frontpaper1
MAOA/MAOB Neuromodulator / circadian / kynurenine 5 4 docs
Matched on MAO-A MAO-B MAOA MAOB monoamine oxidase
Often named withAPOECD38IDO1IL6KMOPARP1
  1. PARP Inhibitors and the Locus Coeruleuspaper2
  2. The Depression Continuumpaper1
  3. The Tryptophan Partitionpaper1
  4. The Viral Trajectorypaper1
MTHFR Trophic / exercise / resilience 5 2 docs
Matched on MTHFR
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. Mapping the Vascular Dimension Onto the Genetic Dimensionpaper3
  2. MTHFR as catalytic pre-existing factorconcept2
SYK Microglia & innate immunity 5 5 docs
Matched on SYK
Often named withMTORTREM2TYROBPACAN (aggrecan)APOEAPP
  1. Metabolic-Homeostatic Axisnode1
  2. The Genetic Architecture of Neurodegenerationpaper1
  3. The Mitochondrion as Nexuspaper1
  4. The Temporal Architecture of Collapsepaper1
  5. The Unified Architecture of Collapsepaper1
SYNJ1 Down-syndrome chr21 5 1 doc
Matched on SYNJ1
Often named withACAN (aggrecan)ADAMTS1ADAMTS4ADAMTS5AGER (RAGE)APOE
  1. The Compressed Architecturepaper5
GPX1 Oxidative stress & ferroptosis 4 3 docs
Matched on GPX1
Often named withAIFM2 (FSP1)ALOX15APOEFTH1/FTL (ferritin)GPX4NFE2L2 (NRF2)
  1. Iron Chelation and GPX4 Stabilizationpaper2
  2. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  3. The Genetic Architecture of Neurodegenerationpaper1
HMOX1 Oxidative stress & ferroptosis 4 2 docs
Matched on HMOX1 HO-1 heme oxygenase
Often named withAIFM2 (FSP1)ALOX15APOEFTH1/FTL (ferritin)GPX1GPX4
  1. Ferroptosis and the Phase II Oligodendrocyte Crisispaper2
  2. Iron Chelation and GPX4 Stabilizationpaper2
LPL Microglia & innate immunity 4 4 docs
Matched on LPL
Often named withAPOEITGAXNLRP3TREM2C1QAC3
  1. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  2. The Cellular Architecture of Collapsepaper1
  3. The DAM Trajectory and the Matrix-degrading Armpaper1
  4. The Temporal Architecture of Collapsepaper1
NPTX2 Reelin, synapse & ECM–PNN 4 2 docs
Matched on NPTX2 Narp
Often named withACAN (aggrecan)APOEBCAN (brevican)C1QAC4 (complement)DAB1
  1. The Matrix of Collapsepaper3
  2. The Unified Architecture of Collapsepaper1
TET1/2/3 Epigenetic & senescence 4 1 doc
Matched on TET1 TET2 TET3
Often named withABI3ADAM10APOEAPPBACE1CD33
  1. The Architecture of Resistancepaper4
TH (tyrosine hydroxylase) Neuromodulator / circadian / kynurenine 4 4 docs
Matched on tyrosine hydroxylase
Often named withAPOEAPPCD38FTH1/FTL (ferritin)P2RY12PARP1
  1. Iron Chelation and GPX4 Stabilizationpaper1
  2. PARP Inhibitors and the Locus Coeruleuspaper1
  3. The Cellular Architecture of Collapsepaper1
  4. The Genetic Architecture of Neurodegenerationpaper1
IDE Amyloid & Tau core 3 2 docs
Matched on IDE
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. IDE-insulin-Abeta competitionconcept2
  2. The Genetic Architecture of Neurodegenerationpaper1
IGF1 Trophic / exercise / resilience 3 1 doc
Matched on IGF-?1
Often named withACAN (aggrecan)APOEAPPBCAN (brevican)BDNFFNDC5 (irisin)
  1. The Adult-born Neuronpaper3
MTNR1A/B Neuromodulator / circadian / kynurenine 3 1 doc
Matched on MTNR1A MTNR1B melatonin receptor
Often named withAPOEARNTL (BMAL1)
  1. The Pineal Interfacepaper3
RCAN1 Down-syndrome chr21 3 1 doc
Matched on RCAN1 DSCR1
Often named withACAN (aggrecan)ADAMTS1ADAMTS4ADAMTS5AGER (RAGE)APOE
  1. The Compressed Architecturepaper3
SPP1 Microglia & innate immunity 3 3 docs
Matched on SPP1 osteopontin
Often named withACAN (aggrecan)APOEAPPBCAN (brevican)C1QAC3
  1. The Cellular Architecture of Collapsepaper1
  2. The Genetic Architecture of Neurodegenerationpaper1
  3. The Temporal Architecture of Collapsepaper1
TXN Oxidative stress & ferroptosis 3 2 docs
Matched on thioredoxin TXN
Often named withACAN (aggrecan)APOEAPPBACE1BIN1C1QA
  1. The Mitochondrion as Nexuspaper2
  2. The Genetic Architecture of Neurodegenerationpaper1
TXNIP Microglia & innate immunity 3 2 docs
Matched on TXNIP
Often named withACAN (aggrecan)APOEAPPATP synthase (ATP5x)BACE1BIN1
  1. TXNIP as therapeutic targetconcept2
  2. The Mitochondrion as Nexuspaper1
VCP Neurodegeneration overlap 3 2 docs
Matched on VCP
Often named withADAM10APOEAPPHSD17B10PINK1TIMM23
  1. The Narrow Gatepaper2
  2. TOMM40 Import Gateconcept1
VEGF Trophic / exercise / resilience 3 2 docs
Matched on VEGF
Often named withAQP4CD38CDKN1A (p21)CDKN2A (p16)FTH1/FTL (ferritin)IL6
  1. The Glymphatic Collapsepaper2
  2. Cellular Senescenceconcept1
VPS4A Autophagy / lysosome / clearance 3 2 docs
Matched on VPS4A
Often named withAPOEAPPATP synthase (ATP5x)BIN1CD38MAP1LC3B (LC3)
  1. The Clearance Collapsepaper2
  2. The Mitochondrion as Nexuspaper1
AIM2 Microglia & innate immunity 2 2 docs
Matched on AIM2
Often named withNLRP3PYCARDTLR4TREM2ABCA7ACSL4
  1. Ferroptosis and the Phase II Oligodendrocyte Crisispaper1
  2. The Sensor and the Speckpaper1
CAT (catalase) Oxidative stress & ferroptosis 2 2 docs
Matched on catalase
Often named withACAN (aggrecan)APOEAPPC1QAC3CX3CR1
  1. The Compressed Architecturepaper1
  2. The Mitochondrion as Nexuspaper1
CDK5 Amyloid & Tau core 2 2 docs
Matched on CDK5
Often named withAPOEPP2AAPPCASP1CX3CR1GSK3B
  1. The Energy-gated Tauopathypaper1
  2. The Silenced Eraserpaper1
CTSD Autophagy / lysosome / clearance 2 2 docs
Matched on CTSD cathepsin D
Often named withACAN (aggrecan)APOEAPPBCAN (brevican)C1QAC3
  1. The Cellular Architecture of Collapsepaper1
  2. The Genetic Architecture of Neurodegenerationpaper1
DNM2 Autophagy / lysosome / clearance 2 1 doc
Matched on DNM2
Often named withAPOEAPPATP synthase (ATP5x)BECN1BIN1CD38
  1. The Clearance Collapsepaper2
FYN Amyloid & Tau core 2 2 docs
Matched on Fyn FYN
Often named withAPOEAPPPSEN1DAB1DLG4 (PSD-95)GSK3B
  1. The Architect's Handshakepaper1
  2. The Case for the Cascadepaper1
IL10 Microglia & innate immunity 2 2 docs
Matched on IL-?10
Often named withAPOEAPPCR3GSK3BC1QAC3
  1. The Trojan Neuroblastpaper1
  2. The Viral Trajectorypaper1
KEAP1 Oxidative stress & ferroptosis 2 1 doc
Matched on KEAP1
Often named withACSL4AIFM2 (FSP1)AIM2ALOX15APOEC1QA
  1. Ferroptosis and the Phase II Oligodendrocyte Crisispaper2
KYNU Neuromodulator / circadian / kynurenine 2 1 doc
Matched on KYNU
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. The Genetic Architecture of Neurodegenerationpaper2
PRNP Neurodegeneration overlap 2 2 docs
Matched on PRNP prion protein PrP
Often named withAPOEAPPPSEN1AIFM2 (FSP1)ALOX15ATP synthase (ATP5x)
  1. Iron Chelation and GPX4 Stabilizationpaper1
  2. The Case for the Cascadepaper1
SV2A Reelin, synapse & ECM–PNN 2 2 docs
Matched on SV2A
Often named withAPOEC1QAC3MMP9NLRP3TREM2
  1. The Complement-pruning Substratepaper1
  2. The Unified Architecture of Collapsepaper1
VPS26 Autophagy / lysosome / clearance 2 2 docs
Matched on VPS26
Often named withAPOEAPPBIN1GPX4MTORNLRP3
  1. The Clearance Collapsepaper1
  2. The Temporal Architecture of Collapsepaper1
GRIN2A Reelin, synapse & ECM–PNN 1 1 doc
Matched on GRIN2A GluN2A NR2A
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. The Genetic Architecture of Neurodegenerationpaper1
NMNAT1 Bioenergetic / mito / NAD 1 1 doc
Matched on NMNAT1
Often named withAPOECD38MAOA/MAOBNAMPTPARP1SARM1
  1. PARP Inhibitors and the Locus Coeruleuspaper1
SHANK3 Reelin, synapse & ECM–PNN 1 1 doc
Matched on SHANK3
Often named withABCA1ABCA7ABI3ACAN (aggrecan)ACSL4ADAMTS4
  1. The Genetic Architecture of Neurodegenerationpaper1
SLC6A2 (NET) Neuromodulator / circadian / kynurenine 1 1 doc
Matched on SLC6A2 norepinephrine transporter
Often named withACAN (aggrecan)APOEAPPBCAN (brevican)DAB1GSK3B
  1. The Coerulean Pincerpaper1
STAT (1/3/6) Microglia & innate immunity 1 1 doc
Matched on STAT1 STAT3 STAT6
Often named withAPOEBDNFCD38GRIN2BIDO1IL6
  1. The Tryptophan Partitionpaper1
TRPML1 Autophagy / lysosome / clearance 1 1 doc
Matched on TRPML1 MCOLN1
Often named withACAN (aggrecan)APOEAPPATP synthase (ATP5x)BACE1BIN1
  1. The Mitochondrion as Nexuspaper1

Method

Counts come from a case-insensitive, word-bounded text scan of each published page — the 123 papers plus the concept, node and stage pages. Each gene matches its symbol and its curated aliases (RELN also counts reelin; APOE counts ApoE4 and apolipoprotein E). A sentence naming two spellings counts twice. The entrant and external-scientist dossiers are withheld from this edition and are not scanned, so these tallies run lower than the full corpus.