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Neuroimmune Interface

Microglial-complement pruning cascade that accelerates synaptic loss through immune-mediated destruction.

Converging Mechanisms

  • C4d deposition on synapses triggers LilrB2 signaling (Shatz/Brott)
  • TREM2-mediated microglial phagocytosis of synapses
  • Pattern recognition of DAMPs (oxidized proteins, Abeta, pTau)
  • Trans-synaptic immune signaling triggers cytoskeletal collapse

Key Molecules

C1q, C3, C4d, LilrB2, TREM2, CR3

To be populated after CSC grading.

See Also

Papers converging on this axis

8
The Unified Architecture of Collapse 1 concept · 6 genes shared Convergent Synaptic Collapse (CSC) — Grading Reference 7 genes shared The Cellular Architecture of Collapse 7 genes shared The Temporal Architecture of Collapse 7 genes shared The Senescent Front 1 concept · 4 genes shared Mapping the Vascular Dimension Onto the Genetic Dimension 6 genes shared The Genetic Architecture of Neurodegeneration 6 genes shared The Proteolytic Turn 6 genes shared

Concepts on this axis

9
Autophagic CollapseCellular SenescenceGut Brain AxisInnate ImmunityMatrix Sulfation NodeNeuroinflammationPerineuronal NetsSynaptic PathologyTau Propagation
Source: kb/wiki/convergence-nodes/neuroimmune-interface.md