WikiAdultCognitiveDisease.com

Stage 4: Neuroimmune Activation

Years 0 to 5

Timeframe: Years 0 to 5 after clinical onset

Complement cascade activated, microglial pruning accelerates. Progressive synaptic loss. Mild-to-moderate cognitive impairment.

Key Events

  • Complement cascade activation
  • Microglial pruning accelerates
  • Progressive synaptic loss
  • Mild-to-moderate impairment

Previous / Next

Cytoskeletal Perturbation | Network Disintegration

Source: kb/wiki/temporal-stages/stage-4-neuroimmune-activation.md