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Stage 2: Endosomal Dysregulation

Years -15 to -5

Timeframe: Years -15 to -5 before clinical onset

Compensatory responses become excessive. Abeta accumulates in endosomes. Retromer dysfunction manifests. Individuals are asymptomatic but amyloid-positive on PET imaging.

Key Events

  • Compensatory responses become excessive
  • Abeta accumulates in endosomes
  • Retromer dysfunction manifests
  • Asymptomatic but amyloid-positive

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Molecular Initiation | Cytoskeletal Perturbation

Source: kb/wiki/temporal-stages/stage-2-endosomal-dysregulation.md