Novel systems analysis approach

Novel Systems Analysis Approach enters the Adult Cognitive Disease corpus through the work of Howard Friel (submission 99), and is indexed here as one of the concepts that submission puts to work.

The argument it belongs to

Howard Friel's submission is summarised in this corpus as:

AD is a complex disease solvable through a novel systems analysis using a three-compound mixture of small molecules (curcumin and EGCG) that multi-targets the amyloid hypothesis and other disease process factors simultaneously. The mono-causal amyloid hypothesis and mono-targeting drug approach have failed, and a systems-level multi-targeting approach addressing both amyloid production and clearance is required.

Where it sits

The submission scores against the framework's convergence nodes as: cytoskeletal collapse 3 · neuroimmune interface 3 · compensatory paradigm 2 · endosomal nexus 1 · transcriptional / epigenetic 1.

Its declared subject matter: systems-analysis, curcumin, EGCG, multi-target, amyloid-hypothesis, small-molecules, drug-failure, polypharmacology.

Named by the same submission

3 other concepts enter the corpus through the same paper, so they cover adjacent ground: Critique of mono-causal therapeutics · Multi-targeting the amyloid hypothesis · Small molecule polypharmacology.

Assembled from the corpus rather than written: the summary is quoted from the submission that named it; the node scores are read from its dossier. It has not yet been expanded into an article.