Endocrine-circadian-inflammation axis

Endocrine-circadian-inflammation axis enters the Adult Cognitive Disease corpus through the work of Anil Kumar Kruthiventi (submission 49), and is indexed here as one of the concepts that submission puts to work.

The argument it belongs to

Anil Kumar Kruthiventi's submission is summarised in this corpus as:

Alzheimer's disease requires a holistic systems-level treatment addressing five causative factors in a 'Quintet': loss of self-esteem and purpose, malfunctioning of pineal/hypothalamus/pituitary glands, disruption of circadian rhythms, subclinical chronic inflammation, and gross physiological changes including amyloid plaque formation. Current treatments only address the last two steps, while the root cause is psychological loss of self-identity and purpose creating a vicious feedback cycle.

Where it sits

The submission scores against the framework's convergence nodes as: neuroimmune interface 3.

Its declared subject matter: holistic medicine, psychosomatic, endocrine system, circadian rhythm, chronic inflammation, self-identity, Ayurveda, mind-body.

Named by the same submission

3 other concepts enter the corpus through the same paper, so they cover adjacent ground: Five-factor quintet model of AD causation · Holistic multi-level therapeutic approach · Psychosomatic cascade to neurodegeneration.

Assembled from the corpus rather than written: the summary is quoted from the submission that named it; the node scores are read from its dossier. It has not yet been expanded into an article.