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Documents 123

The Record5

Disciplinary Silos in Alzheimer's Disease Research, 1950–2020 Fischer's Sidelining How 1907 Observations Predict Modern Findings Mapping 1907 Terms to Modern Science What If We'd Listened to Fischer?

Groundwork23

Astrocytes Huang Is the ER–Mitochondria Contact Site the Real Driver? Khachaturian Khachaturian Mapping the Vascular Dimension Onto the Genetic Dimension The Architecture of Resistance The Cellular Architecture of Collapse The Compressed Architecture The Fading Score The Genetic Architecture of Neurodegeneration The Glial Consortium and the Timeline of Collapse The Janus Lipid The Mitochondrion as Nexus The Muscle's Errand The Narrow Gate The Senescent Front The Vascular Dimension The Vascular Phasing The Wax and the Weld The Withdrawn Subsidy When Myelin's Caretakers Fail When the Brain's Immune Cells Turn Toxic

Phase I16

AG18051 and the Aβ–ABAD Complex NAD⁺ Restoration and CD38 Inhibition PARP Inhibitors and the Locus Coeruleus The Bioenergetic Thesis (Downloadable PDF) The Coerulean Interface The Coerulean Pincer The Coerulean Shears The Energy-gated Tauopathy The Locus Coeruleus & the Noradrenergic Prodrome The Microbial Prologue The Noxious Afferent The Pineal Interface The Restorative Interval The Tryptophan Partition The Vagal Interface The Vago-coerulean Relay

Phase II22

Bioenergetic Collapse Ferroptosis and the Phase II Oligodendrocyte Crisis Fischer's Matrix Homeostatic Microglial Collapse Iron Chelation and GPX4 Stabilization One Sensor, Two Collapses Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer's The Corruption of the Gardener The DAM Trajectory and the Matrix-degrading Arm The Immunometabolic Checkpoint The INFLAMMASOME-COMPLEMENT-TREM2 Nexus The Locus Coeruleus Bridge The Matrix of Collapse The Microglial Thesis (Downloadable PDF) The Net and the Speck The Peacekeeper's Paradox The Perineuronal Turn The Peripheral Arm of Homeostatic Collapse The Proteolytic Turn The Sensor and the Speck The Silenced Eraser The Tide-gate

Phase III16

Convergent Synaptic Collapse (CSC) — Grading Reference Gouras Margolis MMP-9 Inhibitors and the Phase III Therapeutic Window Moosmann & Sohre Ramsden Rappoport Shatz & Brott Small The Adult-born Neuron The Architect's Handshake The Architect's Reprieve The Architect's Scaffold The Complement-pruning Substrate The Pv+/gamma Axis The Trojan Neuroblast

The Spread6

Different Tau Strains Cause Different Diseases How the Brain's Clearance System Becomes the Disease's Highway How α-Synuclein Spreads Through the Brain Proving That Misfolded Proteins Spread Like Prions Why All Major Neurodegenerative Diseases Are the Same Disease Why HMS Becomes HMS+P

The Convergence16

Can Vaccines Protect Against Dementia? Comparing Different Viral Triggers How Free Radicals Disable the Recycling System How Plaques Actually Form How to Fix the Broken Recycling System How Viruses Enter and Hide in the Brain How Viruses Sabotage Brain Cleanup Many Causes, One Bottleneck Plaques Are Tombstones, Not Killers The Cell's Garbage System Controls Aging The Clearance Collapse The Glymphatic Collapse The Viral Trajectory When Poor Blood Flow Causes Dementia Why Damaged Mitochondria Can't Be Cleared Why the Cell's Recycling System Breaks

The Synthesis8

Terminal Collapse The Biomarker Cascade The Case for the Cascade The Depression Continuum The Homeostatic–Matrix–Synaptic (HMS) Collapse Model The Ketamine Paradox The Spectrum of Collapse The Unified Architecture of Collapse

The Frontier6

Testing a Popular Treatment Protocol The Brain's Own Antimicrobial Defense The Gamma Intervention The Therapeutic Landscape of Collapse Vaccines That May Prevent Dementia Why Decline Happens Suddenly, Not Gradually

Convergence nodes7

Endosomal Nexus Cytoskeletal Collapse Node Compensatory Paradigm Nexus Neuroimmune Interface APOE4 Hub Transcriptional-Epigenetic Dysregulation Node Metabolic-Homeostatic Axis

Concepts634 Genes200

Reference6 Temporal stageshistorical

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Home/Concepts/Onset vs Progression

Onset vs Progression

Hypothesis concept submitted by David Rubinsztein. Stub — to be expanded on ingest.

Source: kb/wiki/concepts/onset-vs-progression.md

Compiled from the knowledge base and the research corpus under the ONS methodology · a companion to AdultCognitiveDisease.com. 2026.

775 interlinked articles · 123 theses · 634 concepts · 7 convergence nodes · 5 temporal stages.