Upstream triggers feed a seven-step phase engine — from bioenergetic ignition in the locus coeruleus, across two named bridges, to perineuronal-net digestion — that drives the downstream pathology experienced as dementia. Thicker bands = more central to the path. Hover for strength.
Druggable targets mapped onto the three phases of the Temporal Architecture. Central thesis: most historical trials failed by phase-mismatch — the right mechanism aimed at the wrong phase — not by being the wrong idea.
Each key claim scored across six evidence dimensions and graded on the corpus's three-tier evidentiary scale — Tier I Established, Tier II Bridging inference, Tier III Conjectural. Larger shapes = stronger multi-domain support.
Toggle a patient's decade, genotype and clinical stage to see which stage of the three-phase Temporal Architecture is most engaged. The disease is one homeostatic system failing in three successive cell populations.
A conceptual model of the three-phase Temporal Architecture — not a clinical diagnostic tool. It illustrates how age, genotype and clinical stage engage different stages of the phase engine. The MCI→dementia transition behaves as a threshold — the crossing into a self-sustaining loop — not a smooth slope.
Where the corpus flags genuine, unresolved scientific tension — the structural joints where honest disagreement concentrates. Click any card to see both positions and the current reading.